Baskaran Rajasekaran
Overview
Explore the profile of Baskaran Rajasekaran including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
370
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0
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Recent Articles
1.
Parcha P, Sarvagalla S, Ashok C, Sudharshan S, Dyavaiah M, Coumar M, et al.
Pharmacol Rep
. 2021 Jan;
73(2):615-628.
PMID: 33389727
Background: Papaverine is a benzylisoquinoline alkaloid from the plant Papaver somniferum (Opium poppy). It is approved as an antispasmodic drug by the US FDA and is also reported to have...
2.
Banavath H, Allam S, Valathati S, Sharan A, Rajasekaran B
J Photochem Photobiol B
. 2018 Aug;
187:35-40.
PMID: 30098520
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder occurs in the pluripotent hematopoietic stem cell. Currently, first-generation tyrosine kinase inhibitor (TKI) imatinib is the mainstay for the treatment of CML....
3.
Parcha P, Sarvagalla S, Madhuri B, Pajaniradje S, Baskaran V, Coumar M, et al.
Chem Biol Drug Des
. 2017 Mar;
90(4):596-608.
PMID: 28338290
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the hematopoietic stem cells, characterized at the molecular level by the bcr/abl gene rearrangement. Even though targeting the fusion gene...
4.
Sekar D, Krishnan R, Thirugnanasambantham K, Rajasekaran B, Hairul Islam V, Sekar P
Clin Res Hepatol Gastroenterol
. 2016 May;
40(5):538-545.
PMID: 27179559
Despite promising developments of treatment, the mortality due to gastric cancer remains high and the mechanisms of gastric cancer initiation and the development also remains elusive. It has been reported...
5.
Jiang Z, Kamath R, Jin S, Balasubramani M, Pandita T, Rajasekaran B
Mol Cancer
. 2011 Jul;
10:88.
PMID: 21781306
Background: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function...
6.
Jiang Z, Jin S, Yalowich J, Brown K, Rajasekaran B
Mol Cancer Ther
. 2010 Feb;
9(3):558-68.
PMID: 20145018
The highly conserved mismatch (MMR) repair system corrects postreplicative errors and modulates cellular responses to genotoxic agents. Here, we show that the MMR system strongly influences cellular sensitivity to curcumin....
7.
Kim W, Rajasekaran B, Brown K
J Biol Chem
. 2007 Sep;
282(44):32021-31.
PMID: 17804421
N-Methyl-N'-nitro-N'-nitrosoguanidine (MNNG) is a DNA-methylating agent, and deficiency in mismatch repair (MMR) results in lack of sensitivity to this genotoxin (termed alkylation tolerance). A number of DNA damage response pathways...
8.
Jin S, Mazzacurati L, Zhu X, Tong T, Song Y, Shujuan S, et al.
Oncogene
. 2003 Nov;
22(52):8536-40.
PMID: 14627995
p53 is an important molecule in cellular response to DNA damage. After genotoxic stress, p53 protein stabilizes transiently and accumulates in the nucleus, where it functions as a transcription factor...
9.
10.
Jin S, Tong T, Fan W, Fan F, Antinore M, Zhu X, et al.
Oncogene
. 2002 Dec;
21(57):8696-704.
PMID: 12483522
In response to DNA damage, the cell cycle checkpoint is an important biological event in maintaining genomic fidelity. Gadd45, a p53-regulated and DNA damage inducible protein, has recently been demonstrated...