Bart W Bardoel
Overview
Explore the profile of Bart W Bardoel including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
794
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Recent Articles
1.
Kerkman P, de Vor L, van der Vaart T, Ten Doesschate T, Muts R, Depelteau J, et al.
J Immunol
. 2024 Oct;
213(11):1644-1655.
PMID: 39451041
Staphylococcus aureus is the major cause of healthcare-associated infections, including life-threatening conditions as bacteremia, endocarditis, and implant-associated infections. Despite adequate antibiotic treatment, the mortality of S. aureus bacteremia remains high....
2.
van der Lans S, Bardoel B, Ruyken M, de Haas C, Baijens S, Muts R, et al.
Nat Commun
. 2024 Sep;
15(1):8100.
PMID: 39285158
Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is...
3.
Masson F, Karadottir S, van der Lans S, Doorduijn D, de Haas C, Rooijakkers S, et al.
Sci Rep
. 2024 Sep;
14(1):20701.
PMID: 39237647
The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part...
4.
Egido J, Dekker S, Toner-Bartelds C, Lood C, Rooijakkers S, Bardoel B, et al.
Viruses
. 2023 Nov;
15(11).
PMID: 38005888
Therapeutic bacteriophages (phages) are primarily chosen based on their in vitro bacteriolytic activity. Although anti-phage antibodies are known to inhibit phage infection, the influence of other immune system components is...
5.
Muts R, den Boer M, Bardoel B, Aerts P, de Haas C, Heck A, et al.
Sci Rep
. 2023 Nov;
13(1):18836.
PMID: 37914798
Antibodies play a key role in the immune defence against Gram-negative bacteria. After binding to bacterial surface antigens, IgG and IgM can activate the complement system and trigger formation of...
6.
van der Lans S, Janet-Maitre M, Masson F, Walker K, Doorduijn D, Janssen A, et al.
Sci Rep
. 2023 Aug;
13(1):12618.
PMID: 37537263
Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance. Interestingly, colistin...
7.
Struijf E, De la O Becerra K, Ruyken M, de Haas C, van Oosterom F, Siere D, et al.
J Biol Chem
. 2023 Jun;
299(8):104956.
PMID: 37356719
The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases. Since most unwanted complement effector functions result from C5...
8.
Janet-Maitre M, Pont S, Masson F, Sleiman S, Trouillon J, Robert-Genthon M, et al.
PLoS Pathog
. 2023 Jan;
19(1):e1011023.
PMID: 36696456
Pseudomonas aeruginosa, an opportunistic Gram-negative pathogen, is a leading cause of bacteremia with a high mortality rate. We recently reported that P. aeruginosa forms a persister-like sub-population of evaders in...
9.
Egido J, Toner-Bartelds C, Costa A, Brouns S, Rooijakkers S, Bardoel B, et al.
Sci Rep
. 2023 Jan;
13(1):856.
PMID: 36646746
Bacteriophages (phages) are viruses that specifically attack bacteria. Their use as therapeutics, which constitutes a promising alternative to antibiotics, heavily relies on selecting effective lytic phages against the pathogen of...
10.
Doorduijn D, Lukassen M, van t Wout M, Franc V, Ruyken M, Bardoel B, et al.
Elife
. 2022 Aug;
11.
PMID: 35947526
The membrane attack complex (MAC or C5b-9) is an important effector of the immune system to kill invading microbes. MAC formation is initiated when complement enzymes on the bacterial surface...