Suzan H M Rooijakkers
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Explore the profile of Suzan H M Rooijakkers including associated specialties, affiliations and a list of published articles.
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95
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2981
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Recent Articles
1.
Magda M, Boschloo W, Bettoni S, Fairley D, Russo T, Giske C, et al.
J Innate Immun
. 2025 Jan;
17(1):112-125.
PMID: 39842423
Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body...
2.
Kerkman P, de Vor L, van der Vaart T, Ten Doesschate T, Muts R, Depelteau J, et al.
J Immunol
. 2024 Oct;
213(11):1644-1655.
PMID: 39451041
Staphylococcus aureus is the major cause of healthcare-associated infections, including life-threatening conditions as bacteremia, endocarditis, and implant-associated infections. Despite adequate antibiotic treatment, the mortality of S. aureus bacteremia remains high....
3.
Hendriks A, Kerkman P, Varkila M, Haitsma Mulier J, Ali S, Ten Doesschate T, et al.
Cell Rep Med
. 2024 Sep;
5(9):101734.
PMID: 39293400
Staphylococcus aureus is a major human pathogen, yet the immune factors that protect against infection remain elusive. High titers of opsonic IgG antibodies, achieved in preclinical animal immunization studies, have...
4.
van der Lans S, Bardoel B, Ruyken M, de Haas C, Baijens S, Muts R, et al.
Nat Commun
. 2024 Sep;
15(1):8100.
PMID: 39285158
Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is...
5.
Masson F, Karadottir S, van der Lans S, Doorduijn D, de Haas C, Rooijakkers S, et al.
Sci Rep
. 2024 Sep;
14(1):20701.
PMID: 39237647
The Gram-negative bacterium Klebsiella pneumoniae is an important human pathogen. Its treatment has been complicated by the emergence of multi-drug resistant strains. The human complement system is an important part...
6.
Yin V, Desligniere E, Mokiem N, Gazi I, Lood R, de Haas C, et al.
J Am Soc Mass Spectrom
. 2024 May;
35(6):1320-1329.
PMID: 38767111
Immunoglobulins M (IgM) are key natural antibodies produced initially in humoral immune response. Due to their large molecular weights and extensive glycosylation loads, IgMs represent a challenging target for conventional...
7.
Kalaidopoulou Nteak S, Vollmy F, Lukassen M, van den Toorn H, den Boer M, Bondt A, et al.
J Proteome Res
. 2024 May;
23(6):2124-2136.
PMID: 38701233
Using proteomics and complexome profiling, we evaluated in a year-long study longitudinal variations in the plasma proteome of kidney failure patients, prior to and after a kidney transplantation. The post-transplant...
8.
Foss S, Sakya S, Aguinagalde L, Lustig M, Shaughnessy J, Cruz A, et al.
Nat Commun
. 2024 Mar;
15(1):2007.
PMID: 38453922
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive...
9.
Oskam N, den Boer M, Lukassen M, Ooijevaar-De Heer P, Veth T, van Mierlo G, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2311265120.
PMID: 38055740
Immunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity, and the first antibody isotype to emerge during an immune response. IgM is a large (1 MDa), multimeric...
10.
Dijkstra D, van de Bovenkamp F, Abendstein L, Zuijderduijn R, Pool J, Kramer C, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(50):e2310666120.
PMID: 38048459
Autoantibodies directed against complement component C1q are commonly associated with autoimmune diseases, especially systemic lupus erythematosus. Importantly, these anti-C1q autoantibodies are specific for ligand-bound, solid-phase C1q and do not bind...