Bart J L Eggen
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Explore the profile of Bart J L Eggen including associated specialties, affiliations and a list of published articles.
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113
Citations
4099
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Recent Articles
1.
Rajicic A, Giannini L, Gerrits E, van Buuren R, Melhem S, Slotman J, et al.
Glia
. 2024 Dec;
PMID: 39705191
A subpopulation of astrocytes expressing WD Repeat Domain 49 (WDR49) was recently identified in frontotemporal lobar degeneration (FTLD) with GRN pathogenic variants. This is the first study to investigate their...
2.
Matera A, Compagnion A, Pedicone C, Kotah J, Ivanov A, Monsorno K, et al.
Immunity
. 2024 Dec;
58(1):197-217.e13.
PMID: 39657671
The gene inositol polyphosphate-5-phosphatase D (INPP5D), which encodes the lipid phosphatase SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is associated with the risk of Alzheimer's disease (AD). How it influences microglial...
3.
Sabogal-Guaqueta A, Mitchell-Garcia T, Hunneman J, Voshart D, Thiruvalluvan A, Foijer F, et al.
Neurobiol Dis
. 2024 Nov;
203:106742.
PMID: 39581553
Microglia represent the main resident immune cells of the brain. The interplay between microglia and other cells in the central nervous system, such as neurons or other glial cells, influences...
4.
Alsema A, Wijering M, Miedema A, Kotah J, Koster M, Rijnsburger M, et al.
Nat Neurosci
. 2024 Nov;
27(12):2341-2353.
PMID: 39501035
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progressive neurodegeneration. To understand MS lesion initiation and progression, we generate spatial gene...
5.
Alsema A, Puvogel S, Kracht L, Webster M, Weickert C, Eggen B, et al.
Brain
. 2024 Oct;
PMID: 39397771
Dysfunctional GABAergic and dopaminergic neurons are thought to exist in the ventral midbrain of patients with schizophrenia, yet transcriptional changes underpinning these abnormalities have not yet been localized to specific...
6.
Kotah J, Eggen B
Immunity
. 2024 Sep;
57(9):2005-2007.
PMID: 39260352
Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that...
7.
Rosenzweig N, Kleemann K, Rust T, Carpenter M, Grucci M, Aronchik M, et al.
Nat Med
. 2024 Jul;
30(10):2990-3003.
PMID: 38961225
APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non-APOE4 carriers. Leveraging single-cell...
8.
Oshima T, Kater M, Huffels C, Wesseling E, Middeldorp J, Hol E, et al.
J Neurosci Res
. 2024 Mar;
102(3):e25295.
PMID: 38515329
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau. Many AD risk...
9.
Mekkes N, Groot M, Hoekstra E, de Boer A, Dagkesamanskaia E, Bouwman S, et al.
Nat Med
. 2024 Mar;
30(4):1143-1153.
PMID: 38472295
Neurodegenerative disorders exhibit considerable clinical heterogeneity and are frequently misdiagnosed. This heterogeneity is often neglected and difficult to study. Therefore, innovative data-driven approaches utilizing substantial autopsy cohorts are needed to...
10.
Voshart D, Oshima T, Jiang Y, van der Linden G, Ainslie A, Reali Nazario L, et al.
Cell Rep
. 2024 Feb;
43(2):113764.
PMID: 38358885
Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline....