Erik W G M Boddeke
Overview
Explore the profile of Erik W G M Boddeke including associated specialties, affiliations and a list of published articles.
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25
Citations
1476
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Recent Articles
1.
Oshima T, Kater M, Huffels C, Wesseling E, Middeldorp J, Hol E, et al.
J Neurosci Res
. 2024 Mar;
102(3):e25295.
PMID: 38515329
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau. Many AD risk...
2.
van Weering H, Nijboer T, Brummer M, Boddeke E, Eggen B
Glia
. 2023 Jun;
71(10):2356-2371.
PMID: 37293807
Microglia are the resident macrophages of the central nervous system (CNS) and play a pivotal role in immune surveillance and CNS homeostasis. Morphological transitions in microglia are indicative for local...
3.
Vainchtein I, Alsema A, Dubbelaar M, Grit C, Vinet J, van Weering H, et al.
Glia
. 2022 Nov;
71(3):588-601.
PMID: 36377669
Multiple sclerosis (MS) is the most common inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. Chronic-relapsing experimental autoimmune encephalomyelitis (crEAE) in Biozzi ABH mice is...
4.
Kater M, Huffels C, Oshima T, Renckens N, Middeldorp J, Boddeke E, et al.
Brain Behav Immun
. 2022 Oct;
107:225-241.
PMID: 36270437
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, the neuropathological formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. The best cellular correlates of the early cognitive deficits...
5.
Gerrits E, Giannini L, Brouwer N, Melhem S, Seilhean D, Le Ber I, et al.
Nat Neurosci
. 2022 Jul;
25(8):1034-1048.
PMID: 35879464
Frontotemporal dementia (FTD) is the second most prevalent form of early-onset dementia, affecting predominantly frontal and temporal cerebral lobes. Heterozygous mutations in the progranulin gene (GRN) cause autosomal-dominant FTD (FTD-GRN),...
6.
Zhang X, Kracht L, Lerario A, Dubbelaar M, Brouwer N, Wesseling E, et al.
J Neuroinflammation
. 2022 May;
19(1):111.
PMID: 35568856
Background: Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A...
7.
Heng Y, Zhang X, Borggrewe M, van Weering H, Brummer M, Nijboer T, et al.
J Neuroinflammation
. 2021 Feb;
18(1):57.
PMID: 33618716
Background: An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively....
8.
Gerrits E, Brouwer N, Kooistra S, Woodbury M, Vermeiren Y, Lambourne M, et al.
Acta Neuropathol
. 2021 Feb;
141(5):681-696.
PMID: 33609158
Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads. Microglia, the tissue-resident...
9.
Borggrewe M, Grit C, Vainchtein I, Brouwer N, Wesseling E, Laman J, et al.
Glia
. 2020 Dec;
69(5):1140-1154.
PMID: 33332631
Astrocytes fulfil many functions in the central nervous system (CNS), including contribution to the blood brain barrier, synapse formation, and trophic support. In addition, they can mount an inflammatory response...
10.
Heng Y, Dubbelaar M, Marie S, Boddeke E, Eggen B
Glia
. 2020 Dec;
69(4):1053-1060.
PMID: 33296111
Microglia are specialized macrophages of the central nervous system (CNS) and first to react to pathogens or injury. Over the last decade, transcriptional profiling of microglia significantly contributed to our...