Susanne M Kooistra
Overview
Explore the profile of Susanne M Kooistra including associated specialties, affiliations and a list of published articles.
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28
Citations
1077
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Recent Articles
1.
Kooistra S, Schirmer L
Glia
. 2024 Dec;
73(3):574-590.
PMID: 39719685
Multiple sclerosis (MS) is the most prevalent human inflammatory disease of the central nervous system with demyelination and glial scar formation as pathological hallmarks. Glial cells are key drivers of...
2.
Alsema A, Wijering M, Miedema A, Kotah J, Koster M, Rijnsburger M, et al.
Nat Neurosci
. 2024 Nov;
27(12):2341-2353.
PMID: 39501035
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and progressive neurodegeneration. To understand MS lesion initiation and progression, we generate spatial gene...
3.
Voshart D, Oshima T, Jiang Y, van der Linden G, Ainslie A, Reali Nazario L, et al.
Cell Rep
. 2024 Feb;
43(2):113764.
PMID: 38358885
Over half of patients with brain tumors experience debilitating and often progressive cognitive decline after radiotherapy treatment. Microglia, the resident macrophages in the brain, have been implicated in this decline....
4.
Oost W, Huitema A, Kats K, Giepmans B, Kooistra S, Eggen B, et al.
Acta Neuropathol Commun
. 2023 Jun;
11(1):100.
PMID: 37340488
Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which...
5.
Reemst K, Kracht L, Kotah J, Rahimian R, van Irsen A, Congrains Sotomayor G, et al.
Transl Psychiatry
. 2022 Dec;
12(1):507.
PMID: 36481769
Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including depression later in life. Neuroinflammatory processes have been implicated in ELS-induced negative health outcomes, but how ELS impacts microglia,...
6.
Vainchtein I, Alsema A, Dubbelaar M, Grit C, Vinet J, van Weering H, et al.
Glia
. 2022 Nov;
71(3):588-601.
PMID: 36377669
Multiple sclerosis (MS) is the most common inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. Chronic-relapsing experimental autoimmune encephalomyelitis (crEAE) in Biozzi ABH mice is...
7.
Zhang X, Kracht L, Lerario A, Dubbelaar M, Brouwer N, Wesseling E, et al.
J Neuroinflammation
. 2022 May;
19(1):111.
PMID: 35568856
Background: Microglia are the tissue-resident macrophages of the CNS. They originate in the yolk sac, colonize the CNS during embryonic development and form a self-sustaining population with limited turnover. A...
8.
Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, et al.
Acta Neuropathol Commun
. 2022 Jan;
10(1):8.
PMID: 35090578
Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several...
9.
Amor S, McNamara N, Gerrits E, Marzin M, Kooistra S, Miron V, et al.
Acta Neuropathol
. 2021 Dec;
143(2):125-141.
PMID: 34878590
Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in shaping the brain during development, responding to invading pathogens, and clearing tissue debris or aberrant...
10.
Borggrewe M, Kooistra S, Wesseling E, Gierschek F, Brummer M, Nowak E, et al.
Acta Neuropathol Commun
. 2021 May;
9(1):91.
PMID: 34006329
V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid cells regulates cytokine...