Bart J L Eggen
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Explore the profile of Bart J L Eggen including associated specialties, affiliations and a list of published articles.
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113
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4099
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Recent Articles
11.
Puvogel S, Alsema A, North H, Webster M, Weickert C, Eggen B
eNeuro
. 2024 Feb;
11(3).
PMID: 38351133
The subependymal zone (SEZ), also known as the subventricular zone (SVZ), constitutes a neurogenic niche that persists during postnatal life. In humans, the neurogenic potential of the SEZ declines after...
12.
Ainslie A, Klaver M, Voshart D, Gerrits E, den Dunnen W, Eggen B, et al.
Aging Cell
. 2024 Jan;
23(3):e14066.
PMID: 38234228
Progressive neurocognitive dysfunction is the leading cause of a reduced quality of life in patients with primary brain tumors. Understanding how the human brain responds to cancer and its treatment...
13.
Yousefzadeh M, Huerta Guevara A, Postmus A, Flores R, Sano T, Jurdzinski A, et al.
Aging Biol
. 2023 Dec;
1(1).
PMID: 38124711
Age is the greatest risk factor for the development of type 2 diabetes mellitus (T2DM). Age-related decline in organ function is attributed to the accumulation of stochastic damage, including damage...
14.
Eskandar S, Bezemer R, Eggen B, Prins J
J Immunol
. 2023 Nov;
211(12):1868-1876.
PMID: 37909834
Isolation of placental macrophages using enzymatic digestion at warm temperatures is widely used for in vitro studies. However, studies in brain and kidney tissue show that this method activates immune...
15.
Sabogal-Guaqueta A, Marmolejo-Garza A, Trombetta-Lima M, Oun A, Hunneman J, Chen T, et al.
Nat Commun
. 2023 Oct;
14(1):6454.
PMID: 37833292
Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other...
16.
Yin Z, Rosenzweig N, Kleemann K, Zhang X, Brandao W, Margeta M, et al.
Nat Immunol
. 2023 Sep;
24(11):1839-1853.
PMID: 37749326
The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched...
17.
18.
Oost W, Huitema A, Kats K, Giepmans B, Kooistra S, Eggen B, et al.
Acta Neuropathol Commun
. 2023 Jun;
11(1):100.
PMID: 37340488
Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which...
19.
van Weering H, Nijboer T, Brummer M, Boddeke E, Eggen B
Glia
. 2023 Jun;
71(10):2356-2371.
PMID: 37293807
Microglia are the resident macrophages of the central nervous system (CNS) and play a pivotal role in immune surveillance and CNS homeostasis. Morphological transitions in microglia are indicative for local...
20.
Scheepstra K, Mizee M, van Scheppingen J, Adelia A, Wever D, Mason M, et al.
Biol Psychiatry
. 2023 Apr;
94(8):619-629.
PMID: 37121366
Background: Microglia have been implicated in the pathophysiology of major depressive disorder (MDD), but information on biological mechanisms is limited. Therefore, we investigated the gene expression profile of microglial cells...