Barbora Svobodova
Overview
Explore the profile of Barbora Svobodova including associated specialties, affiliations and a list of published articles.
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29
Citations
417
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Recent Articles
1.
Falcones B, Kahnt M, Johansson U, Svobodova B, von Wachenfelt K, Brunmark C, et al.
Cell Commun Signal
. 2025 Feb;
23(1):67.
PMID: 39920750
Synchrotron-radiation nano-X-Ray Fluorescence (XRF) is a cutting-edge technique offering high-resolution insights into the elemental composition of biological tissues, shedding light on metabolic processes and element localization within cellular structures. In...
2.
Kassa J, Konecny J, Svobodova B, Horak M, Korabecny J, Soukup O
Chem Biol Interact
. 2025 Jan;
407():111386.
PMID: 39805415
The current pharmacological pretreatment and medical treatment of nerve agent poisoning is an insufficiently addressed medical task. The prophylactic efficacy of a novel compound acting dually as an acetylcholinesterase inhibitor...
3.
Svobodova B, Lofdahl A, Nybom A, Wigen J, Hirdman G, Olm F, et al.
Biomedicines
. 2025 Jan;
12(12.
PMID: 39767799
A novel patient group with chronic pulmonary fibrosis is emerging post COVID-19. To identify patients at risk of developing post-COVID-19 lung fibrosis, we here aimed to identify systemic proteins that...
4.
Misiachna A, Svobodova B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, et al.
Eur J Med Chem
. 2024 Jan;
266:116130.
PMID: 38218127
Tacrine (THA), a long withdrawn drug, is still a popular scaffold used in medicinal chemistry, mainly for its good reactivity and multi-targeted effect. However, THA-associated hepatotoxicity is still an issue...
5.
Novak M, Vajrychova M, Koutsilieri S, Sismanoglou D, Kobrlova T, Prchal L, et al.
ACS Chem Biol
. 2023 Aug;
18(9):1993-2002.
PMID: 37622522
Tacrine was withdrawn from clinical use as a drug against Alzheimer's disease in 2013, mainly due to drug-induced liver injury. The culprit of tacrine-associated hepatotoxicity is believed to be the...
6.
Svobodova B, Pulkrabkova L, Panek D, Misiachna A, Kolcheva M, Andrys R, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298087
Alzheimer's disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and -methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies have...
7.
Pulkrabkova L, Svobodova B, Konecny J, Kobrlova T, Muckova L, Janousek J, et al.
Arch Toxicol
. 2022 Nov;
97(1):39-72.
PMID: 36335468
Organophosphorus compounds (OP) are a constant problem, both in the military and in the civilian field, not only in the form of acute poisoning but also for their long-lasting consequences....
8.
Novotny J, Svobodova B, Santrucek J, Fukal L, Karamonova L
Appl Environ Microbiol
. 2022 Apr;
88(9):e0250821.
PMID: 35435719
Members of the genus are responsible for severe infections in infants and immunosuppressed individuals. Although several virulence factors have been described, many proteins involved in the pathogenesis of such infections...
9.
Zhou Y, Arribas G, Turku A, Jurgenson T, Mkrtchian S, Krebs K, et al.
Sci Adv
. 2021 Sep;
7(36):eabi6856.
PMID: 34516913
Interindividual variability in drug response constitutes a major concern in pharmacotherapy. While polymorphisms in genes involved in drug disposition have been extensively studied, drug target variability remains underappreciated. By mapping...
10.
Svobodova B, Jelinkova S, Pesl M, Beckerova D, Lacampagne A, Meli A, et al.
Pflugers Arch
. 2021 Jun;
473(7):1099-1115.
PMID: 34169350
Duchenne muscular dystrophy is a genetic disorder where an X-linked mutation in the DMD gene initiates pathogenic development caused by the absence of dystrophin protein. This impacts primarily the evolution...