Bachuki Shashikadze
Overview
Explore the profile of Bachuki Shashikadze including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
62
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Recent Articles
1.
Jaudas F, Bartenschlager F, Shashikadze B, Santamaria G, Reichart D, Schnell A, et al.
Sci Transl Med
. 2025 Jan;
17(782):eadk9145.
PMID: 39841805
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator...
2.
Raj Murthi S, Petry A, Shashikadze B, Stockl J, Schmid M, Santamaria G, et al.
Sci Rep
. 2025 Jan;
15(1):2132.
PMID: 39820339
Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. HCM is associated with myocardial hypertrophy, fibrosis and ventricular...
3.
Sen P, Hamers J, Sittig T, Shashikadze B, dAmbrosio L, Stockl J, et al.
Basic Res Cardiol
. 2024 Oct;
119(6):957-971.
PMID: 39404904
Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine identified changes in microvascular structure and function, as well as changes in mitochondrial structure and...
4.
Shashikadze B, Flenkenthaler F, Kemter E, Franzmeier S, Stockl J, Haid M, et al.
Dis Model Mech
. 2024 Jun;
17(7).
PMID: 38900131
Growing evidence shows that the lung is an organ prone to injury by diabetes mellitus. However, the molecular mechanisms of these pulmonary complications have not yet been characterized comprehensively. To...
5.
Horanszky A, Shashikadze B, Elkhateib R, Lombardo S, Lamberto F, Zana M, et al.
Front Cell Dev Biol
. 2023 Sep;
11:1236243.
PMID: 37664457
Bisphenol A (BPA) exposure is associated with a plethora of neurodevelopmental abnormalities and brain disorders. Previous studies have demonstrated BPA-induced perturbations to critical neural stem cell (NSC) characteristics, such as...
6.
Lamberto F, Shashikadze B, Elkhateib R, Lombardo S, Horanszky A, Balogh A, et al.
Environ Pollut
. 2023 Aug;
335:122359.
PMID: 37567409
Early embryonic development represents a sensitive time-window during which the foetus might be vulnerable to the exposure of environmental contaminants, potentially leading to heart diseases also later in life. Bisphenol...
7.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stockl J, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2301250120.
PMID: 37428903
Duchenne muscular dystrophy (DMD) is a fatal X-linked disease caused by mutations in the gene, leading to complete absence of dystrophin and progressive degeneration of skeletal musculature and myocardium. In...
8.
Shashikadze B, Valla L, Lombardo S, Prehn C, Haid M, Riols F, et al.
Mol Metab
. 2023 Jul;
75:101768.
PMID: 37414142
Objective: To gain mechanistic insights into adverse effects of maternal hyperglycemia on the liver of neonates, we performed a multi-omics analysis of liver tissue from piglets developed in genetically diabetic...
9.
Shashikadze B, Franzmeier S, Hofmann I, Kraetzl M, Flenkenthaler F, Blutke A, et al.
J Neuroendocrinol
. 2023 May;
36(7):e13277.
PMID: 37160285
Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 (IGF1) and high, but non-functional serum growth hormone (GH) levels in human Laron syndrome (LS) patients and...
10.
Sen P, Shashikadze B, Flenkenthaler F, Van de Kamp E, Tian S, Meng C, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902298
Pulmonary vein stenosis (PVS) causes a rare type of pulmonary hypertension (PH) by impacting the flow and pressure within the pulmonary vasculature, resulting in endothelial dysfunction and metabolic changes. A...