B Lutterbach
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Explore the profile of B Lutterbach including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
906
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Recent Articles
1.
Reed-Inderbitzin E, Moreno-Miralles I, Vanden-Eynden S, Xie J, Lutterbach B, Durst-Goodwin K, et al.
Oncogene
. 2006 May;
25(42):5777-86.
PMID: 16652147
RUNX1 (AML1) is a gene that is frequently disrupted by chromosomal translocations in acute leukemia. Like its Drosophila homolog Runt, RUNX1 both activates and represses transcription. Both Runt and RUNX1...
2.
Heibert S, Lutterbach B, Durst K, Wang L, Linggi B, Wu S, et al.
Cancer Chemother Pharmacol
. 2001 Oct;
48 Suppl 1:S31-4.
PMID: 11587363
AML-1 is one of the most frequently translocated genes in human leukemia. AML-1 binds DNA and activates or represses transcription, while the chromosomal translocation fusion proteins in acute myeloid leukemia...
3.
Hiebert S, Lutterbach B, Amann J
Curr Opin Hematol
. 2001 Sep;
8(4):197-200.
PMID: 11561155
The t(8;21), t(16;21), inv(16), and t(12;21) are some of the most frequent chromosomal translocations found in acute myeloid and acute lymphoblastic leukemia. The fusion proteins created by these chromosomal translocations...
4.
Amann J, Nip J, Strom D, Lutterbach B, Harada H, Lenny N, et al.
Mol Cell Biol
. 2001 Sep;
21(19):6470-83.
PMID: 11533236
t(8;21) and t(16;21) create two fusion proteins, AML-1-ETO and AML-1-MTG16, respectively, which fuse the AML-1 DNA binding domain to putative transcriptional corepressors, ETO and MTG16. Here, we show that distinct...
5.
Gregory M, Xiao Q, Cornwall G, Lutterbach B, Hann S
Oncogene
. 2000 Oct;
19(42):4886-95.
PMID: 11039906
The myc family of genes plays an important role in several cellular processes including proliferation, apoptosis, differentiation, and transformation. B-myc, a relatively new and largely unstudied member of the myc...
6.
Lutterbach B, Hiebert S
Gene
. 2000 Mar;
245(2):223-35.
PMID: 10717473
Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal...
7.
Melnick A, Westendorf J, Polinger A, Carlile G, Arai S, Ball H, et al.
Mol Cell Biol
. 2000 Feb;
20(6):2075-86.
PMID: 10688654
The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML). The resulting AML-1-ETO...
8.
Strom D, Nip J, Westendorf J, Linggi B, Lutterbach B, Downing J, et al.
J Biol Chem
. 2000 Feb;
275(5):3438-45.
PMID: 10652337
The AML-1-encoded transcription factor, AML-1B, regulates numerous hematopoietic-specific genes. Inappropriate expression of AML-1-family proteins is oncogenic in cell culture systems and in mice. To understand the oncogenic functions of AML-1,...
9.
Lutterbach B, Westendorf J, Linggi B, Isaac S, Seto E, Hiebert S
J Biol Chem
. 2000 Jan;
275(1):651-6.
PMID: 10617663
AML1 is one of the most frequently translocated genes in human leukemia. Here we demonstrate that acute myeloid leukemia-1 (AML-1) (Runx-1) represses transcription from a native promoter, p21(Waf1/Cip1). Unexpectedly, this...
10.
Lutterbach B, Hou Y, Durst K, Hiebert S
Proc Natl Acad Sci U S A
. 1999 Oct;
96(22):12822-7.
PMID: 10536006
The inv(16) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). The inv(16) fusion protein acts by dominantly interfering with AML-1/core binding factor beta-dependent transcriptional...