J J Westendorf
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Explore the profile of J J Westendorf including associated specialties, affiliations and a list of published articles.
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20
Citations
716
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Recent Articles
1.
Taylor E, Weaver S, Zars E, Turner C, Buhrow S, Reid J, et al.
Osteoarthr Cartil Open
. 2022 Dec;
3(3):100190.
PMID: 36474816
Objective: The pleckstrin homology domain leucine-rich repeat protein phosphatases (Phlpp1/2) were recently identified as potential therapeutic targets for cartilage regeneration in osteoarthritic joints. Phlpp inhibitors NSC 117079 and NSC 45586...
2.
Pierce J, Begun D, Westendorf J, McGee-Lawrence M
Bone
. 2018 May;
118:2-7.
PMID: 29782940
Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of...
3.
Bradley E, Carpio L, McGee-Lawrence M, Castillejo Becerra C, Amanatullah D, Ta L, et al.
Osteoarthritis Cartilage
. 2016 Jan;
24(6):1021-8.
PMID: 26746148
Objective: Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability. OA is characterized by articular chondrocyte deterioration, subchondral bone changes and debilitating pain. One...
4.
Westendorf J
J Biol Chem
. 2001 Oct;
276(49):46453-9.
PMID: 11590143
FHOS is a member of the formin homology (FH) family of proteins and is expressed at high levels in splenic cells. FH proteins link cellular signaling pathways to the actin...
5.
Melnick A, Westendorf J, Polinger A, Carlile G, Arai S, Ball H, et al.
Mol Cell Biol
. 2000 Feb;
20(6):2075-86.
PMID: 10688654
The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML). The resulting AML-1-ETO...
6.
Strom D, Nip J, Westendorf J, Linggi B, Lutterbach B, Downing J, et al.
J Biol Chem
. 2000 Feb;
275(5):3438-45.
PMID: 10652337
The AML-1-encoded transcription factor, AML-1B, regulates numerous hematopoietic-specific genes. Inappropriate expression of AML-1-family proteins is oncogenic in cell culture systems and in mice. To understand the oncogenic functions of AML-1,...
7.
Westendorf J, Hiebert S
J Cell Biochem
. 2000 Jan;
Suppl 32-33:51-8.
PMID: 10629103
Mammalian Runt-domain-containing factors are structurally and functionally similar and have essential roles in hematopoiesis and osteogenesis. These factors can act as either positive or negative transcriptional regulators of tissue-specific genes...
8.
Lutterbach B, Westendorf J, Linggi B, Isaac S, Seto E, Hiebert S
J Biol Chem
. 2000 Jan;
275(1):651-6.
PMID: 10617663
AML1 is one of the most frequently translocated genes in human leukemia. Here we demonstrate that acute myeloid leukemia-1 (AML-1) (Runx-1) represses transcription from a native promoter, p21(Waf1/Cip1). Unexpectedly, this...
9.
Fenrick R, Amann J, Lutterbach B, Wang L, Westendorf J, Downing J, et al.
Mol Cell Biol
. 1999 Sep;
19(10):6566-74.
PMID: 10490596
t(12;21) is the most frequent translocation found in pediatric B-cell acute lymphoblastic leukemias. This translocation fuses a putative repressor domain from the TEL DNA-binding protein to nearly all of the...
10.
Westendorf J, Mernaugh R, Hiebert S
Gene
. 1999 Jun;
232(2):173-82.
PMID: 10352228
A novel member of the Formin/Diaphanous family of proteins was cloned and characterized. A 4kB mRNA is ubiquitously expressed but is found in abundance in the spleen. FHOS (Formin Homologue...