B C Crews
Overview
Explore the profile of B C Crews including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
33
Citations
693
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Recent Articles
1.
Kozak K, Crews B, Ray J, Tai H, Morrow J, Marnett L
J Biol Chem
. 2001 Jul;
276(40):36993-8.
PMID: 11447235
Prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) are generated by the action of cyclooxygenase-2 on the endocannabinoids 2-arachidonylglycerol (2-AG) and arachidonylethanolamide, respectively. These novel eicosanoids may have unique pharmacological...
2.
Boutaud O, Brame C, Chaurand P, Li J, Rowlinson S, Crews B, et al.
Biochemistry
. 2001 Jun;
40(23):6948-55.
PMID: 11389610
These investigations characterize the covalent binding of reactive products of prostaglandin H-synthases (PGHSs) to the enzyme and to other molecules. The intermediate product of oxygenation of arachidonic acid by the...
3.
ODonnell V, Coles B, Lewis M, Crews B, Marnett L, Freeman B
J Biol Chem
. 2000 Sep;
275(49):38239-44.
PMID: 10993875
Nitric oxide (( small middle dot)NO) plays a central role in vascular homeostasis via regulation of smooth muscle relaxation and platelet aggregation. Although mechanisms for ( small middle dot)NO formation...
4.
Kalgutkar A, Marnett A, Crews B, Remmel R, Marnett L
J Med Chem
. 2000 Aug;
43(15):2860-70.
PMID: 10956194
Recent studies from our laboratory have shown that derivatization of the carboxylate moiety in substrate analogue inhibitors, such as 5,8,11,14-eicosatetraynoic acid, and in nonsteroidal antiinflammatory drugs (NSAIDs), such as indomethacin...
5.
Marnett L, Wright T, Crews B, Tannenbaum S, Morrow J
J Biol Chem
. 2000 May;
275(18):13427-30.
PMID: 10788454
We investigated the effects of targeted deletion of the inducible NO synthase (iNOS) gene on the formation of prostaglandins in vivo and ex vivo. Peritoneal macrophages were obtained from control...
6.
Rowlinson S, Crews B, Goodwin D, Schneider C, Gierse J, Marnett L
J Biol Chem
. 2000 Feb;
275(9):6586-91.
PMID: 10692466
The two isoforms of cyclooxygenase, COX-1 and COX-2, are acetylated by aspirin at Ser-530 and Ser-516, respectively, in the cyclooxygenase active site. Acetylated COX-2 is essentially a lipoxygenase, making 15-(R)-hydroxyeicosatetraenoic...
7.
Kalgutkar A, Crews B, Rowlinson S, Garner C, Marnett L
Adv Exp Med Biol
. 2000 Feb;
469:139-43.
PMID: 10667322
No abstract available.
8.
Kalgutkar A, Crews B, Rowlinson S, Marnett A, Kozak K, Remmel R, et al.
Proc Natl Acad Sci U S A
. 2000 Jan;
97(2):925-30.
PMID: 10639181
All nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) isozymes to different extents, which accounts for their anti-inflammatory and analgesic activities and their gastrointestinal side effects. We have exploited biochemical...
9.
Montine T, Sidell K, Crews B, Markesbery W, Marnett L, Roberts 2nd L, et al.
Neurology
. 1999 Oct;
53(7):1495-8.
PMID: 10534257
Objective: To determine CSF eicosanoid concentrations and brain cyclo-oxygenase activity in AD patients and age-matched control subjects. Background: Nonsteroidal anti-inflammatory drugs may benefit AD patients by inhibiting cyclo-oxygenases and thereby...
10.
Daniel T, Liu H, Morrow J, Crews B, Marnett L
Cancer Res
. 1999 Sep;
59(18):4574-7.
PMID: 10493510
Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of stimuli, suggesting that products of COX-2 may mediate critical steps. Here, we show that thromboxane A2 (TXA2) is one of...