Avik K Ghosh
Overview
Explore the profile of Avik K Ghosh including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
384
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0
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Recent Articles
1.
Ferrarelli L, Popuri V, Ghosh A, Tadokoro T, Canugovi C, Hsu J, et al.
DNA Repair (Amst)
. 2013 May;
12(7):518-28.
PMID: 23683351
Telomeres are critical for cell survival and functional integrity. Oxidative DNA damage induces telomeric instability and cellular senescence that are associated with normal aging and segmental premature aging disorders such...
2.
Singh D, Popuri V, Kulikowicz T, Shevelev I, Ghosh A, Ramamoorthy M, et al.
Nucleic Acids Res
. 2012 May;
40(14):6632-48.
PMID: 22544709
Bacteria and yeast possess one RecQ helicase homolog whereas humans contain five RecQ helicases, all of which are important in preserving genome stability. Three of these, BLM, WRN and RECQL4,...
3.
Ghosh A, Rossi M, Singh D, Dunn C, Ramamoorthy M, Croteau D, et al.
J Biol Chem
. 2011 Nov;
287(1):196-209.
PMID: 22039056
Telomeres are structures at the ends of chromosomes and are composed of long tracks of short tandem repeat DNA sequences bound by a unique set of proteins (shelterin). Telomeric DNA...
4.
Ramamoorthy M, Tadokoro T, Rybanska I, Ghosh A, Wersto R, May A, et al.
Nucleic Acids Res
. 2011 Oct;
40(4):1621-35.
PMID: 22013166
DNA decatenation mediated by Topoisomerase II is required to separate the interlinked sister chromatids post-replication. SGS1, a yeast homolog of the human RecQ family of helicases interacts with Topoisomerase II...
5.
Singh D, Ghosh A, Croteau D, Bohr V
Mutat Res
. 2011 Jun;
736(1-2):15-24.
PMID: 21689668
Organisms are constantly exposed to various environmental insults which could adversely affect the stability of their genome. To protect their genomes against the harmful effect of these environmental insults, organisms...
6.
Rossi M, Ghosh A, Kulikowicz T, Croteau D, Bohr V
DNA Repair (Amst)
. 2010 May;
9(7):796-804.
PMID: 20451470
Humans have five members of the well conserved RecQ helicase family: RecQ1, Bloom syndrome protein (BLM), Werner syndrome protein (WRN), RecQ4, and RecQ5, which are all known for their roles...
7.
Rossi M, Ghosh A, Bohr V
DNA Repair (Amst)
. 2010 Jan;
9(3):331-44.
PMID: 20075015
Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated in the maintenance of genome stability. The conserved RecQ family also includes RecQ1, Bloom syndrome...
8.
Nucleotide excision repair of a DNA interstrand cross-link produces single- and double-strand breaks
Peng X, Ghosh A, Van Houten B, Greenberg M
Biochemistry
. 2009 Dec;
49(1):11-9.
PMID: 20000382
The DNA radical resulting from formal abstraction of a hydrogen atom from the thymidine methyl group, 5-(2'-deoxyuridinyl)methyl radical, forms interstrand cross-links with the opposing 2'-deoxyadenosine. This is the first chemically...
9.
Joy A, Ghosh A, Schuster G
J Am Chem Soc
. 2006 Apr;
128(16):5346-7.
PMID: 16620098
The anthraquinone (AQ) photosensitized one-electron oxidation of DNA introduces a radical cation (electron "hole") that migrates through the duplex by hopping. The radical cation normally is trapped irreversibly by reaction...
10.
Ghosh A, Schuster G
J Am Chem Soc
. 2006 Mar;
128(13):4172-3.
PMID: 16568960
Oxidation of a guanine nucleobase to its radical cation in DNA oligomers causes an increase in the acidity of the N1 imino proton that may lead to its spontaneous transfer...