Atul D Jain
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Explore the profile of Atul D Jain including associated specialties, affiliations and a list of published articles.
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9
Citations
322
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Recent Articles
1.
Xu W, Zhao Z, Su M, Jain A, Lloyd H, Feng E, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2415976121.
PMID: 39793072
C-Terminal cyclic imides are posttranslational modifications that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events...
2.
Han X, Mei Y, Mishra R, Bi H, Jain A, Schiltz G, et al.
J Clin Invest
. 2023 Jan;
133(6).
PMID: 36719747
Myeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. We previously revealed...
3.
Lazzara P, Jain A, Maldonado A, Richardson B, Skowron K, David B, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):521-527.
PMID: 32292559
The oxidative stress response, gated by the protein-protein interaction of KEAP1 and NRF2, has garnered significant interest in the past decade. Misregulation in this pathway has been implicated in disease...
4.
Han H, Jain A, Truica M, Izquierdo-Ferrer J, Anker J, Lysy B, et al.
Cancer Cell
. 2019 Nov;
36(5):483-497.e15.
PMID: 31679823
Small molecules that directly target MYC and are also well tolerated in vivo will provide invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a series of small-molecule MYC...
5.
Izquierdo J, Jain A, Abdulkadir S, Schiltz G
Synthesis (Stuttg)
. 2019 Jul;
51(6):1342-1352.
PMID: 31274934
The chromenone core is a ubiquitous group in biologically-active natural products and has been extensively used in organic synthesis. Fluorine derived compounds, including those with a trifluoromethyl group (-CF), have...
6.
Richardson B, Jain A, Potteti H, Lazzara P, David B, Tamatam C, et al.
J Med Chem
. 2018 Aug;
61(17):8029-8047.
PMID: 30122040
Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription...
7.
Wei C, Bajpai R, Sharma H, Heitmeier M, Jain A, Matulis S, et al.
Eur J Med Chem
. 2017 Aug;
139:573-586.
PMID: 28837922
Cancer cells consume more glucose to fuel metabolic programs fundamental to sustaining their survival, growth and proliferation. Among the fourteen SLC2A family members, GLUTs 1 and 4 are high-affinity glucose...
8.
Yao Y, Kong C, Yin L, Jain A, Ratia K, Thatcher G, et al.
Chemistry
. 2016 Oct;
23(4):752-756.
PMID: 27734530
Herein, we report the design, synthesis, and characterization of a lanthanide complex-based probe for the time-gated luminescence detection of hydrogen sulfide (H S) in aqueous media. The probe's unique sensing...
9.
Jain A, Potteti H, Richardson B, Kingsley L, Luciano J, Ryuzoji A, et al.
Eur J Med Chem
. 2015 Sep;
103:252-68.
PMID: 26363505
Activation of the transcription factor Nrf2 has been posited to be a promising therapeutic strategy in a number of inflammatory and oxidative stress diseases due to its regulation of detoxifying...
10.
Hamouda A, Wang Z, Stewart D, Jain A, Glennon R, Cohen J
Mol Pharmacol
. 2015 Apr;
88(1):1-11.
PMID: 25870334
Desformylflustrabromine (dFBr) is a positive allosteric modulator (PAM) of α4β2 and α2β2 nAChRs that, at concentrations >1 µM, also inhibits these receptors and α7 nAChRs. However, its interactions with muscle-type...