Brian P David
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Explore the profile of Brian P David including associated specialties, affiliations and a list of published articles.
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6
Citations
66
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Recent Articles
1.
Barakat M, Han C, Chen L, David B, Shi J, Xu A, et al.
Sci Rep
. 2024 Oct;
14(1):25258.
PMID: 39448644
The transcription factor NRF2 plays an important role in many biological processes and is a promising therapeutic target for many disease states. NRF2 is highly expressed in the skin and...
2.
Lazzara P, Jain A, Maldonado A, Richardson B, Skowron K, David B, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):521-527.
PMID: 32292559
The oxidative stress response, gated by the protein-protein interaction of KEAP1 and NRF2, has garnered significant interest in the past decade. Misregulation in this pathway has been implicated in disease...
3.
Lazzara P, David B, Ankireddy A, Richardson B, Dye K, Ratia K, et al.
J Med Chem
. 2019 Nov;
63(12):6547-6560.
PMID: 31682434
Pharmacological activation of NRF2 (nuclear factor erythroid 2-related factor 2) arises from blocking the interaction of NRF2 with its negative regulator, KEAP1 (Kelch-like ECH-associated protein 1). We previously reported an...
4.
Skowron K, Booker K, Cheng C, Creed S, David B, Lazzara P, et al.
Mol Cell Endocrinol
. 2019 Jun;
493:110471.
PMID: 31163202
The purpose of this review is to highlight recent developments in small molecules and peptides that block the binding of coactivators to steroid receptors. These coactivator binding inhibitors bind at...
5.
Richardson B, Jain A, Potteti H, Lazzara P, David B, Tamatam C, et al.
J Med Chem
. 2018 Aug;
61(17):8029-8047.
PMID: 30122040
Activators of nuclear factor-erythroid 2-related factor 2 (NRF2) could lead to promising therapeutics for prevention and treatment of oxidative stress and inflammatory disorders. Ubiquitination and subsequent degradation of the transcription...
6.
David B, Dubrovskyi O, Speltz T, Wolff J, Frasor J, Sanchez L, et al.
ACS Med Chem Lett
. 2018 Jul;
9(7):768-772.
PMID: 30034616
Matrix assisted laser desorption ionization time-of-flight (MALDI-TOF) imaging mass spectrometry has emerged as a powerful, label-free technique to visualize penetration of small molecules and , including in 3D cell culture...