Astrid E Alewijnse
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Explore the profile of Astrid E Alewijnse including associated specialties, affiliations and a list of published articles.
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30
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742
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Recent Articles
11.
Spijkers L, Alewijnse A, Peters S
Mol Cells
. 2010 Feb;
29(2):105-11.
PMID: 20127284
Vasomotor tone is regulated by a complex interplay of a variety of extrinsic neurohumoral and intrinsic factors. It is the endothelium that has a major influence on smooth muscle cell...
12.
Van Borren M, Verkerk A, Wilders R, Hajji N, Zegers J, Bourier J, et al.
Basic Res Cardiol
. 2009 Jul;
105(1):73-87.
PMID: 19639379
We investigated the contribution of the intracellular calcium (Ca (i) (2+) ) transient to acetylcholine (ACh)-mediated reduction of pacemaker frequency and cAMP content in rabbit sinoatrial nodal (SAN) cells. Action...
13.
Hendriks-Balk M, Hajji N, van Loenen P, Michel M, Peters S, Alewijnse A
Eur J Pharmacol
. 2009 Apr;
606(1-3):25-31.
PMID: 19374869
Regulator of G protein signalling (RGS) protein expression is altered under growth promoting conditions in vascular smooth muscle cells (VSMCs). Since sphingosine-1-phosphate (S1P) is an important growth stimulatory factor, we...
14.
Vrydag W, Alewijnse A, Michel M
Br J Pharmacol
. 2009 Jan;
156(1):127-34.
PMID: 19133996
Background And Purpose: beta(3)-Adrenoceptors mediate many important physiological functions, for example, in the urinary bladder. The corresponding gene is polymorphic, and the W64R (Trp64Arg) single nucleotide polymorphism has been associated...
15.
Barendrecht M, Frazier E, Vrydag W, Alewijnse A, Peters S, Michel M
Neurourol Urodyn
. 2008 Nov;
28(4):349-55.
PMID: 19034955
Aims: To explore possible changes in expression and/or function of alpha(1)- and beta-adrenoceptor subtypes as a cause for bladder dysfunction in a rat model of bladder outlet obstruction (BOO). Methods:...
16.
Hahntow I, Mairuhu G, van Valkengoed I, Baas F, Alewijnse A, Koopmans R, et al.
Am J Hypertens
. 2008 Nov;
22(1):80-6.
PMID: 19023274
Background: Polymorphisms in the Regulator of G-protein Signaling 2 (RGS2) gene have been reported to be associated with hypertension (HT) in Japanese women and black Americans of either gender but...
17.
Hendriks-Balk M, van Loenen P, Hajji N, Michel M, Peters S, Alewijnse A
Eur J Pharmacol
. 2008 Oct;
600(1-3):1-9.
PMID: 18854184
Sphingosine-1-phosphate (S1P) signalling via G protein-coupled receptors is important for the regulation of cell function and differentiation. Specific Regulators of G protein Signalling (RGS) proteins modulate the function of these...
18.
Mulders A, Mathy M, Heringdorf D, ter Braak M, Hajji N, Olthof D, et al.
Basic Res Cardiol
. 2008 Sep;
104(1):50-9.
PMID: 18777003
Local formation of the sphingomyelin metabolite sphingosine-1-phosphate (S1P) within the vascular wall has been shown to modulate vascular reactivity. In this study we investigated whether sphingosine kinase, the enzyme responsible...
19.
Alewijnse A, Peters S
Eur J Pharmacol
. 2008 Apr;
585(2-3):292-302.
PMID: 18420192
Sphingolipids are biologically active lipids that play important roles in various cellular processes and the sphingomyelin metabolites ceramide, sphingosine and sphingosine-1-phosphate can act as signalling molecules in most cell types....
20.
Hendriks-Balk M, Peters S, Michel M, Alewijnse A
Eur J Pharmacol
. 2008 Apr;
585(2-3):278-91.
PMID: 18410914
G protein-coupled receptors (GPCRs) are involved in many biological processes. Therefore, GPCR function is tightly controlled both at receptor level and at the level of signalling components. Well-known mechanisms by...