Astrid C E Linthorst
Overview
Explore the profile of Astrid C E Linthorst including associated specialties, affiliations and a list of published articles.
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22
Citations
1130
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Recent Articles
1.
Bhake R, Russell G, Kershaw Y, Stevens K, Zaccardi F, Warburton V, et al.
J Clin Endocrinol Metab
. 2019 Sep;
105(4).
PMID: 31529059
Context: In humans, approximately 95% of circulating cortisol is bound to corticosteroid-binding globulin and albumin. It is only the free fraction that is biologically active and can activate signaling pathways...
2.
Reul J, Collins A, Saliba R, Mifsud K, Carter S, Gutierrez-Mecinas M, et al.
Neurobiol Stress
. 2016 Sep;
1:44-59.
PMID: 27589660
Glucocorticoid hormones play a pivotal role in the response to stressful challenges. The surge in glucocorticoid hormone secretion after stress needs to be tightly controlled with characteristics like peak height,...
3.
Agorastos A, Linthorst A
J Pineal Res
. 2016 Apr;
61(1):3-26.
PMID: 27061919
Loss of circadian rhythmicity fundamentally affects the neuroendocrine, immune, and autonomic system, similar to chronic stress and may play a central role in the development of stress-related disorders. Recent articles...
4.
Bjorngaard J, Carslake D, Nilsen T, Linthorst A, Davey Smith G, Gunnell D, et al.
PLoS One
. 2015 Jul;
10(7):e0131708.
PMID: 26167892
Objective: While high body mass index is associated with an increased risk of depression and anxiety, cumulative evidence indicates that it is a protective factor for suicide. The associations from...
5.
Wlodarczyk A, Sylantyev S, Herd M, Kersante F, Lambert J, Rusakov D, et al.
J Neurosci
. 2013 Mar;
33(9):3905-14.
PMID: 23447601
Activation of GABA(A) receptors (GABA(A)Rs) produces two forms of inhibition: phasic inhibition generated by the rapid, transient activation of synaptic GABA(A)Rs by presynaptic GABA release, and tonic inhibition generated by...
6.
Kersante F, Rowley S, Pavlov I, Gutierrez-Mecinas M, Semyanov A, Reul J, et al.
J Physiol
. 2013 Feb;
591(10):2429-41.
PMID: 23381899
Tonic γ-aminobutyric acid (GABA)A receptor-mediated signalling controls neuronal network excitability in the hippocampus. Although the extracellular concentration of GABA (e[GABA]) is critical in determining tonic conductances, knowledge on how e[GABA]...
7.
Qian X, Droste S, Lightman S, Reul J, Linthorst A
Endocrinology
. 2012 Jul;
153(9):4346-53.
PMID: 22822164
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadian rhythm that is made up from an underlying series of hormone pulses. In blood most of...
8.
Qian X, Droste S, Gutierrez-Mecinas M, Collins A, Kersante F, Reul J, et al.
Endocrinology
. 2011 Aug;
152(10):3738-48.
PMID: 21828178
A strict control of glucocorticoid hormone responses to stress is essential for health. In blood, glucocorticoid hormones are for the largest part bound to corticosteroid-binding globulin (CBG), and just a...
9.
Droste S, Collins A, Lightman S, Linthorst A, Reul J
Endocrinology
. 2009 May;
150(9):4170-9.
PMID: 19477935
Previous work has shown that allowing rats to voluntarily exercise in a running wheel for 4 wk modifies the hypothalamic-pituitary-adrenal axis and behavioral coping responses to stress. To investigate whether...
10.
Droste S, de Groote L, Atkinson H, Lightman S, Reul J, Linthorst A
Endocrinology
. 2008 Mar;
149(7):3244-53.
PMID: 18356272
Circulating corticosterone levels show an ultradian rhythm resulting from the pulsatile release of glucocorticoid hormone by the adrenal cortex. Because the pattern of hormone availability to corticosteroid receptors is of...