Stafford L Lightman
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Explore the profile of Stafford L Lightman including associated specialties, affiliations and a list of published articles.
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148
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4912
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Recent Articles
1.
Rakshasa-Loots A, Steyn C, Swiffen D, Marwick K, Semple R, Reynolds R, et al.
BMC Psychiatry
. 2025 Feb;
25(1):122.
PMID: 39948527
People with severe mental illness have high rates of obesity, type 2 diabetes, and cardiovascular disease. Emerging evidence suggests that metabolic dysfunction may be causally linked to the risk of...
2.
Klaas S, Upton T, Zavala E, Lawton M, Bensing S, Berinder K, et al.
Proc Biol Sci
. 2025 Jan;
292(2038):20241844.
PMID: 39809311
Cortisol is released upon activation of the hypothalamic-pituitary-adrenal axis, varies across the day, possesses an underlying diurnal rhythm and is responsive to stressors. The endogenous circadian peak of cortisol occurs...
3.
Paul S, De Visser A, Motta F, Rivers C, Pooley J, Lightman S, et al.
Steroids
. 2024 Nov;
214:109524.
PMID: 39490722
Mineralocorticoid (MR) and glucocorticoid receptors (GR) act as transcription factors and major mediators of glucocorticoid signalling, with pivotal roles in regulating the stress response and hormonal signalling, mood, cognition and...
4.
Lee J, Meyer E, Nenke M, Lightman S, Torpy D
J Clin Endocrinol Metab
. 2024 Jun;
109(9):2161-2172.
PMID: 38941154
Selye described stress as a unified neurohormonal mechanism maintaining homeostasis. Acute stress system activation is adaptive through neurocognitive, catecholaminergic, and immunomodulation mechanisms, followed by a reset via cortisol. Stress system...
5.
Lightman S, Conway-Campbell B
J Intern Med
. 2024 Jun;
296(2):121-138.
PMID: 38825772
The hypothalamic-pituitary-adrenal axis is an extremely dynamic system with a combination of both circadian and ultradian oscillations. This state of 'continuous dynamic equilibration' provides a platform that is able to...
6.
Jackson M, Lightman S, Robinson E
Behav Brain Res
. 2024 Apr;
466:114977.
PMID: 38570074
Apathy is a complex psychiatric syndrome characterised by motivational deficit, emotional blunting and cognitive changes. It occurs alongside a broad range of neurological disorders, but also occurs in otherwise healthy...
7.
Lightman S
J Endocr Soc
. 2024 Mar;
8(4):bvae024.
PMID: 38440109
Measurement of blood levels of circulating hormones has always been the cornerstone of the biochemical diagnosis of endocrine diseases, with the objective of detecting hormone excess or insufficiency. Unfortunately, the...
8.
Russell G, Kalafatakis K, Durant C, Marchant N, Thakrar J, Thirard R, et al.
J Intern Med
. 2023 Oct;
295(1):51-67.
PMID: 37857352
Background: Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A pulsatile subcutaneous pump can closely replicate cortisol's circadian...
9.
Marinelli I, Walker J, Seneviratne U, DSouza W, Cook M, Anderson C, et al.
PLoS Comput Biol
. 2023 Oct;
19(10):e1010508.
PMID: 37797040
Epilepsy is a serious neurological disorder characterised by a tendency to have recurrent, spontaneous, seizures. Classically, seizures are assumed to occur at random. However, recent research has uncovered underlying rhythms...
10.
Yoshimura M, Flynn B, Kershaw Y, Zhao Z, Ueta Y, Lightman S, et al.
Commun Biol
. 2023 Sep;
6(1):998.
PMID: 37775688
Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon most commonly associated with shift-work and...