Astrid C E Linthorst
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Explore the profile of Astrid C E Linthorst including associated specialties, affiliations and a list of published articles.
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22
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1130
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Recent Articles
11.
Linthorst A, Reul J
Pharmacol Biochem Behav
. 2007 Nov;
90(2):163-73.
PMID: 18028991
Aberrant functioning of the hypothalamic-pituitary-adrenocortical (HPA) axis seems to be involved in depression and anxiety. However, the mechanisms underlying the relationship between stress and mental illness are not completely resolved...
12.
Linthorst A, Flachskamm C, Reul J
Stress
. 2007 Sep;
11(2):88-100.
PMID: 17853068
Forced swimming is a behavioural stress model increasingly used to investigate the neurocircuitry of stress responses. Although forced swim stress clearly is a psychological stressor (anxiety, panic), its physical aspects...
13.
Droste S, Chandramohan Y, Hill L, Linthorst A, Reul J
Neuroendocrinology
. 2007 Jun;
86(1):26-37.
PMID: 17595533
Introduction: Evidence is accumulating that the regular performance of exercise is beneficial for stress coping. However, the hypothalamic-pituitary-adrenocortical (HPA) axis of voluntarily exercising rats has never been comprehensively investigated. Methods:...
14.
Bachmann C, Bilang-Bleuel A, De Carli S, Linthorst A, Reul J
Neuroendocrinology
. 2005 Jun;
81(2):129-36.
PMID: 15970644
Glucocorticoid receptor (GR) antagonists can block the retention of the immobility response in the forced swimming test. Recently, we showed that forced swimming evokes a distinct spatiotemporal pattern of cAMP-responsive...
15.
de Groote L, Penalva R, Flachskamm C, Reul J, Linthorst A
J Neurochem
. 2005 Jun;
94(1):45-56.
PMID: 15953348
Corticotropin-releasing factor (CRF) mediates various aspects of the stress response. To differentiate between the roles of CRF(1) and CRF(2) receptor subtypes in monoaminergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity and behaviour we...
16.
Beekman M, Flachskamm C, Linthorst A
Eur J Neurosci
. 2005 Jun;
21(10):2825-36.
PMID: 15926930
Clinical studies and animal models have provided evidence that stress and serotonin may play a role in the aetiology of psychiatric diseases such as depression and anxiety. In addition, reciprocal...
17.
Oshima A, Flachskamm C, Reul J, Holsboer F, Linthorst A
Neuropsychopharmacology
. 2003 Aug;
28(12):2148-59.
PMID: 12915860
Antagonists of the corticotropin-releasing hormone receptor type 1 (CRH-R1) are regarded as promising tools for the treatment of stress-related psychiatric disorders. Owing to the intricate relationship between CRH and serotonin...
18.
Cota D, Marsicano G, Tschop M, Grubler Y, Flachskamm C, Schubert M, et al.
J Clin Invest
. 2003 Aug;
112(3):423-31.
PMID: 12897210
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice...
19.
Droste S, Gesing A, Ulbricht S, Muller M, Linthorst A, Reul J
Endocrinology
. 2003 Jun;
144(7):3012-23.
PMID: 12810557
We studied the effects of long-term (i.e. 4 wk) voluntary exercise on the hypothalamic-pituitary-adrenocortical (HPA) axis in male mice. Voluntary exercise was provided by giving mice access to a running...
20.
Penalva R, Lancel M, Flachskamm C, Reul J, Holsboer F, Linthorst A
Eur J Neurosci
. 2003 May;
17(9):1896-906.
PMID: 12752789
Brainstem serotonergic neurotransmission is implicated in sleep regulation. However, the role of serotonin (5-HT) in forebrain regions in sleep-wake mechanisms is still unclear. Here, we have investigated, using a combined...