Astraea Jager
Overview
Explore the profile of Astraea Jager including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
1707
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0
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Recent Articles
1.
Liu Y, Jiang H, Liu J, Stuani L, Merchant M, Jager A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975156
Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of B-cell developmental signaling pathways and increased glucose consumption with chemo-resistance...
2.
Pan F, Sarno J, Jeong J, Yang X, Jager A, Gruber T, et al.
J Clin Invest
. 2023 Nov;
134(1).
PMID: 37917159
A t(4;11) leukemia model established from CRISPR-engineered chromosomal translocations between the KMT2A and AFF1 genes recapitulate proteomic, epigenomic, and transcriptomic features of primary patient leukemias.
3.
Sarno J, Domizi P, Liu Y, Merchant M, Pedersen C, Jedoui D, et al.
Nat Commun
. 2023 May;
14(1):2935.
PMID: 37217509
Resistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single-cell proteomic studies in healthy B-cell progenitors, we...
4.
Lo Y, Keyes T, Jager A, Sarno J, Domizi P, Majeti R, et al.
Nat Commun
. 2022 Feb;
13(1):934.
PMID: 35177627
The increasing use of mass cytometry for analyzing clinical samples offers the possibility to perform comparative analyses across public datasets. However, challenges in batch normalization and data integration limit the...
5.
Jager A, Sarno J, Davis K
Methods Mol Biol
. 2020 Nov;
2185:65-76.
PMID: 33165843
Mass cytometry is now a well-established method that enables the measurement of 40-50 markers (generally proteins but transcripts are also possible) in single cells. Analytes are detected via antibodies tagged...
6.
Lin C, Kuehn H, Thauland T, Lee C, de Ravin S, Malech H, et al.
J Clin Immunol
. 2020 Jul;
40(7):1001-1009.
PMID: 32681206
We report the case of a patient with X-linked severe combined immunodeficiency (X-SCID) who survived for over 20 years without hematopoietic stem cell transplantation (HSCT) because of a somatic reversion ...
7.
OHuallachain M, Bava F, Shen M, Dallett C, Paladugu S, Samusik N, et al.
Commun Biol
. 2020 May;
3(1):279.
PMID: 32472089
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
OHuallachain M, Bava F, Shen M, Dallett C, Paladugu S, Samusik N, et al.
Commun Biol
. 2020 May;
3(1):213.
PMID: 32382044
Single-cell omics provide insight into cellular heterogeneity and function. Recent technological advances have accelerated single-cell analyses, but workflows remain expensive and complex. We present a method enabling simultaneous, ultra-high throughput...
9.
Jeong J, Jager A, Domizi P, Pavel-Dinu M, Gojenola L, Iwasaki M, et al.
Blood Adv
. 2019 Oct;
3(19):2825-2835.
PMID: 31582391
Chromosomal rearrangements involving the mixed lineage leukemia () gene, also known as , are often observed in human leukemias and are generally associated with a poor prognosis. To model these...
10.
Sarno J, Savino A, Buracchi C, Palmi C, Pinto S, Bugarin C, et al.
Oncotarget
. 2018 May;
9(33):22872-22885.
PMID: 29796158
Children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) overexpressing the gene () have poor prognosis. CRLF2 protein overexpression leads to activated JAK/STAT signaling and trials are underway using JAK inhibitors...