Asish Dasgupta
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Explore the profile of Asish Dasgupta including associated specialties, affiliations and a list of published articles.
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31
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836
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Recent Articles
11.
Tian L, Wu D, Dasgupta A, Chen K, Mewburn J, Potus F, et al.
Circ Res
. 2020 Mar;
126(12):1723-1745.
PMID: 32216531
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While RV fibrosis reflects changes in the function of resident RV fibroblasts (RVfib), these cells are understudied....
12.
Dasgupta A, Wu D, Tian L, Xiong P, Dunham-Snary K, Chen K, et al.
Compr Physiol
. 2020 Mar;
10(2):713-765.
PMID: 32163206
In lung vascular cells, mitochondria serve a canonical metabolic role, governing energy homeostasis. In addition, mitochondria exist in dynamic networks, which serve noncanonical functions, including regulation of redox signaling, cell...
13.
Dasgupta A, Chen K, Wu D, Hoskin V, Mewburn J, Lima P, et al.
FASEB J
. 2020 Feb;
34(4):5106-5127.
PMID: 32068312
Excessive proliferation and apoptosis-resistance are hallmarks of cancer. Increased dynamin-related protein 1 (Drp1)-mediated mitochondrial fission is one of the mediators of this phenotype. Mitochondrial fission that accompanies the nuclear division...
14.
Wu D, Dasgupta A, Chen K, Neuber-Hess M, Patel J, Hurst T, et al.
FASEB J
. 2020 Jan;
34(1):1447-1464.
PMID: 31914641
Mitochondrial fission is important in physiological processes, including coordination of mitochondrial and nuclear division during mitosis, and pathologic processes, such as the production of reactive oxygen species (ROS) during cardiac...
15.
Xiong P, Tian L, Dunham-Snary K, Chen K, Mewburn J, Neuber-Hess M, et al.
Front Cardiovasc Med
. 2019 Feb;
5:195.
PMID: 30740395
Group 2 pulmonary hypertension (PH), defined as a mean pulmonary arterial pressure ≥25 mmHg with elevated pulmonary capillary wedge pressure >15 mmHg, has no approved therapy and patients often die...
16.
Tian L, Potus F, Wu D, Dasgupta A, Chen K, Mewburn J, et al.
Front Physiol
. 2018 Jul;
9:828.
PMID: 30042687
Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying RV fibrosis in PAH and the role of RV fibroblasts (RVfib) are unknown. Activation...
17.
Chen K, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, et al.
Circulation
. 2018 Feb;
138(3):287-304.
PMID: 29431643
Background: Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The fission mediator dynamin-related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced...
18.
Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, et al.
J Mol Med (Berl)
. 2017 Mar;
95(4):381-393.
PMID: 28265681
Key Messages: Right ventricular ischemia reperfusion (RV-IR) causes RV diastolic dysfunction. IR-induced mitochondrial fission causes RV diastolic dysfunction. In RV-IR Drp1 translocates to mitochondria, binds Fis1 and causes fission and...
19.
Atkins K, Dasgupta A, Chen K, Mewburn J, Archer S
Clin Sci (Lond)
. 2016 Sep;
130(21):1861-74.
PMID: 27660309
Mitochondrial morphology is governed by the balance of mitochondrial fusion, mediated by mitofusins and optic atrophy 1 (OPA1), and fission, mediated by dynamin-related protein 1 (Drp1). Disordered mitochondrial dynamics alters...
20.
Hong Z, Chen K, Dasgupta A, Potus F, Dunham-Snary K, Bonnet S, et al.
Am J Respir Crit Care Med
. 2016 Sep;
195(4):515-529.
PMID: 27648837
Rationale: Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype is promoted by increased...