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Ashwath Jayagopal

Explore the profile of Ashwath Jayagopal including associated specialties, affiliations and a list of published articles. Areas
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Articles 32
Citations 431
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Recent Articles
1.
Magrath G, Luvisi J, Russakoff D, Oakley J, Say E, Say E, et al.
Am J Ophthalmol . 2025 Feb; 273:176-181. PMID: 39986639
Purpose: To utilize a convolutional neural network (CNN) to predict the response of treatment-naïve diabetic macular edema (DME) to a single injection of anti-vascular endothelial growth factor (anti-VEGF) with data...
2.
Jamal S, Dieckmann B, McCollum G, Penn J, Jayagopal A, Imam Uddin M
Microcirculation . 2024 Aug; 31(7):e12883. PMID: 39213162
Purpose: To develop a reliable method to generate a mouse model of branch retinal artery occlusion (BRAO) using laser-induced thrombosis of a major artery in the mouse retina. Also, to...
3.
Liu H, Stepicheva N, Ghosh S, Shang P, Chowdhury O, Daley R, et al.
Nat Commun . 2022 Oct; 13(1):6045. PMID: 36229454
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role...
4.
Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al.
Commun Biol . 2021 Jul; 4(1):850. PMID: 34239035
The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are...
5.
Ghosh S, Liu H, Yazdankhah M, Stepicheva N, Shang P, Vaidya T, et al.
Commun Biol . 2021 Feb; 4(1):248. PMID: 33627831
βA3/A1-crystallin, a lens protein that is also expressed in astrocytes, is produced as βA3 and βA1-crystallin isoforms by leaky ribosomal scanning. In a previous human proteome high-throughput array, we found...
6.
Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H, et al.
Autophagy . 2021 Jan; 17(10):3140-3159. PMID: 33404293
Retinal ganglion cell axons are heavily myelinated (98%) and myelin damage in the optic nerve (ON) severely affects vision. Understanding the molecular mechanism of oligodendrocyte progenitor cell (OPC) differentiation into...
7.
Jayagopal A, Ragelle Guest Editors H
J Ocul Pharmacol Ther . 2019 Oct; 36(1):3. PMID: 31573397
No abstract available.
8.
Ghosh S, Padmanabhan A, Vaidya T, Watson A, Bhutto I, Hose S, et al.
Commun Biol . 2019 Sep; 2:348. PMID: 31552301
Age-related macular degeneration (AMD) is an expanding problem as longevity increases worldwide. While inflammation clearly contributes to vision loss in AMD, the mechanism remains controversial. Here we show that neutrophils...
9.
Kompella U, Domb A, Urtti A, Jayagopal A, Wilson C, Tang-Liu D
J Ocul Pharmacol Ther . 2019 Jul; 35(8):457-465. PMID: 31259643
Ocular drug delivery offers unique challenges and opportunities in the era of novel therapeutic agents ranging from small molecules to gene therapies. Noninvasive delivery of drugs into the back of...
10.
Ragelle H, Goncalves A, Kustermann S, Antonetti D, Jayagopal A
J Ocul Pharmacol Ther . 2019 May; 36(1):30-41. PMID: 31140899
The blood-retinal barrier (BRB) protects the retina by maintaining an adequate microenvironment for neuronal function. Alterations of the junctional complex of the BRB and consequent BRB breakdown in disease contribute...