J Samuel Zigler Jr
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Explore the profile of J Samuel Zigler Jr including associated specialties, affiliations and a list of published articles.
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51
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929
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Recent Articles
1.
Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, et al.
Nat Commun
. 2024 Jul;
15(1):6150.
PMID: 39034314
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and...
2.
Yazdankhah M, Ghosh S, Liu H, Hose S, Zigler Jr J, Sinha D
Cells
. 2023 Oct;
12(20.
PMID: 37887340
Mitochondrial dysfunction in astrocytes has been implicated in the development of various neurological disorders. Mitophagy, mitochondrial autophagy, is required for proper mitochondrial function by preventing the accumulation of damaged mitochondria....
3.
Daley R, Maddipatla V, Ghosh S, Chowdhury O, Hose S, Zigler Jr J, et al.
Cell Death Discov
. 2023 Jul;
9(1):243.
PMID: 37443129
Diabetic Retinopathy (DR) is a complication of diabetes that causes blindness in adults. Retinal fibrosis is closely associated with developing proliferative diabetic retinopathy (PDR). Clinical studies have shown that fibrotic...
4.
Liu H, Ghosh S, Vaidya T, Bammidi S, Huang C, Shang P, et al.
JCI Insight
. 2023 Jun;
8(12).
PMID: 37345657
Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon...
5.
Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, et al.
Cells
. 2022 Nov;
11(22).
PMID: 36428965
In dry age-related macular degeneration (AMD), inflammation plays a key role in disease pathogenesis. Innate immune cells such as microglia and neutrophils infiltrate the sub-retinal space (SRS) to induce chronic...
6.
Liu H, Stepicheva N, Ghosh S, Shang P, Chowdhury O, Daley R, et al.
Nat Commun
. 2022 Oct;
13(1):6045.
PMID: 36229454
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role...
7.
Gupta U, Ghosh S, Wallace C, Shang P, Xin Y, Nair A, et al.
Autophagy
. 2022 Apr;
19(1):92-111.
PMID: 35473441
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented...
8.
Shang P, Stepicheva N, Liu H, Chowdhury O, Franks J, Sun M, et al.
Int J Mol Sci
. 2021 Nov;
22(21).
PMID: 34769409
Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured...
9.
Shang P, Stepicheva N, Teel K, McCauley A, Fitting C, Hose S, et al.
Commun Biol
. 2021 Jul;
4(1):850.
PMID: 34239035
The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the back of the eye. High membrane turnover and polarization, including formation of actin-based apical microvilli, are...
10.
Ghosh S, Liu H, Yazdankhah M, Stepicheva N, Shang P, Vaidya T, et al.
Commun Biol
. 2021 Feb;
4(1):248.
PMID: 33627831
βA3/A1-crystallin, a lens protein that is also expressed in astrocytes, is produced as βA3 and βA1-crystallin isoforms by leaky ribosomal scanning. In a previous human proteome high-throughput array, we found...