Ashraf S Ibrahim
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Explore the profile of Ashraf S Ibrahim including associated specialties, affiliations and a list of published articles.
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153
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7248
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Recent Articles
1.
Gu Y, Singh S, Alqarihi A, Alkhazraji S, Gebremariam T, Youssef E, et al.
Sci Transl Med
. 2025 Mar;
17(789):eads7369.
PMID: 40073153
Mucormycosis is a fungal infection caused by Mucorales fungi that cause severe disease and fatality, especially in immunocompromised individuals. Although vaccines and immunotherapeutics have been successful in combating viral and...
2.
Ali B, Chauhan A, Kumar M, Kumar P, Carolus H, Romero C, et al.
J Fungi (Basel)
. 2024 Nov;
10(11).
PMID: 39590679
Certain species of Mucorales have been identified as causative agents of mucormycosis, a rare yet often lethal fungal infection. Notably, these fungi exhibit intrinsic resistance to common azole drugs, which...
3.
Pinzan C, Valero C, de Castro P, Silva J, Earle K, Liu H, et al.
Nat Microbiol
. 2024 Aug;
9(10):2710-2726.
PMID: 39191887
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for initiating host infection. There is scarce information about A. fumigatus proteins involved in fungal evasion and host immunity modulation....
4.
Diehl C, Pinzan C, de Castro P, Delbaje E, Garcia Carnero L, Sanchez-Leon E, et al.
mBio
. 2024 Jun;
15(7):e0103124.
PMID: 38916308
Importance: Invasive fungal infections have a high mortality rate causing more deaths annually than tuberculosis or malaria. Cryptococcosis, one of the most prevalent fungal diseases, is generally characterized by meningitis...
5.
Kavaliauskas P, Gu Y, Hasin N, Graf K, Alqarihi A, Shetty A, et al.
Nat Commun
. 2024 Jun;
15(1):5282.
PMID: 38902255
During pulmonary mucormycosis, inhaled sporangiospores adhere to, germinate, and invade airway epithelial cells to establish infection. We provide evidence that HIF1α plays dual roles in airway epithelial cells during Mucorales...
6.
Gu Y, Gebremariam T, Alkhazraji S, Youssef E, El-Gamal S, Matkovits T, et al.
Antimicrob Agents Chemother
. 2024 Apr;
68(6):e0154023.
PMID: 38687015
Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective...
7.
Gebremariam T, Alkhazraji S, Gu Y, Najvar L, Borroto-Esoda K, Patterson T, et al.
Antimicrob Agents Chemother
. 2024 Apr;
68(5):e0154523.
PMID: 38557112
Ibrexafungerp (formerly SCY-078) is the first member of the triterpenoid class that prevents the synthesis of the fungal cell wall polymer β-(1,3)-D-glucan by inhibiting the enzyme glucan synthase. We evaluated...
8.
Gu Y, Gebremariam T, Alkhazraji S, Youssef E, El-Gamal S, Matkovits T, et al.
bioRxiv
. 2023 Dec;
PMID: 38045251
Invasive mucormycosis (IM) is associated with high mortality and morbidity and commonly afflicts patients with weakened immune systems. MAT2203 is an orally administered lipid nanocrystal (LNC) formulation of amphotericin B,...
9.
Maji A, Soutar C, Zhang J, Lewandowska A, Uno B, Yan S, et al.
Nature
. 2023 Nov;
623(7989):1079-1085.
PMID: 37938782
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin B...
10.
Alqarihi A, Kontoyiannis D, Ibrahim A
Front Cell Infect Microbiol
. 2023 Oct;
13:1254919.
PMID: 37808914
Mucormycosis (MCR) is an emerging and frequently lethal fungal infection caused by the Mucorales family, with , , and , accounting for > 90% of all cases. MCR is seen...