John E Edwards Jr
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Explore the profile of John E Edwards Jr including associated specialties, affiliations and a list of published articles.
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78
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5437
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Recent Articles
1.
Soliman S, Baldin C, Gu Y, Singh S, Gebremariam T, Swidergall M, et al.
Nat Microbiol
. 2021 Jan;
6(3):313-326.
PMID: 33462434
Fungi of the order Mucorales cause mucormycosis, a lethal infection with an incompletely understood pathogenesis. We demonstrate that Mucorales fungi produce a toxin, which plays a central role in virulence....
2.
Iyer K, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo S, Fossen J, et al.
Nat Commun
. 2020 Dec;
11(1):6429.
PMID: 33353950
Candida auris is an emerging fungal pathogen that exhibits resistance to multiple drugs, including the most commonly prescribed antifungal, fluconazole. Here, we use a combinatorial screening approach to identify a...
3.
Filler E, Liu Y, Solis N, Wang L, Diaz L, Edwards Jr J, et al.
Infect Immun
. 2020 Dec;
89(3).
PMID: 33318139
The mechanisms by which resists host defense peptides and caspofungin are incompletely understood. To identify transcriptional regulators that enable to withstand these classes of stressors, a library of 215 transcriptional...
4.
Alqarihi A, Gebremariam T, Gu Y, Swidergall M, Alkhazraji S, Soliman S, et al.
mBio
. 2020 Jun;
11(3).
PMID: 32487760
Mucormycosis, caused by species, is a life-threatening fungal infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA), cytotoxic chemotherapy, immunosuppressive therapy, hematologic malignancies, or severe trauma. Inhaled spores cause...
5.
Singh S, Uppuluri P, Mamouei Z, Alqarihi A, Elhassan H, French S, et al.
PLoS Pathog
. 2019 Aug;
15(8):e1007460.
PMID: 31381597
Candida auris is an emerging, multi-drug resistant, health care-associated fungal pathogen. Its predominant prevalence in hospitals and nursing homes indicates its ability to adhere to and colonize the skin, or...
6.
Gebremariam T, Alkhazraji S, Soliman S, Gu Y, Jeon H, Zhang L, et al.
Sci Adv
. 2019 Jun;
5(6):eaaw1327.
PMID: 31206021
Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that , the most common cause of mucormycosis, invades endothelial cells by binding of its CotH...
7.
Alqarihi A, Singh S, Edwards Jr J, Ibrahim A, Uppuluri P
Sci Rep
. 2019 Apr;
9(1):6194.
PMID: 30996274
NDV-3A, a novel fungal vaccine undergoing clinical trials, contains a recombinant version of the Candida albicans rAls3 N-terminus protein (rAls3p-N) in aluminum hydroxide. In a Phase 1b/2a clinical trial, NDV-3A...
8.
Baldin C, Soliman S, Jeon H, Alkhazraji S, Gebremariam T, Gu Y, et al.
J Clin Microbiol
. 2018 Aug;
56(10).
PMID: 30068535
Mucormycosis is an aggressive, life-threatening infection caused by fungi in the order Mucorales. The current diagnosis of mucormycosis relies on mycological cultures, radiology and histopathology. These methods lack sensitivity and...
9.
Uppuluri P, Lin L, Alqarihi A, Luo G, Youssef E, Alkhazraji S, et al.
PLoS Pathog
. 2018 May;
14(5):e1007056.
PMID: 29746596
Different pathogens share similar medical settings and rely on similar virulence strategies to cause infections. We have previously applied 3-D computational modeling and bioinformatics to discover novel antigens that target...
10.
Edwards Jr J, Schwartz M, Schmidt C, Sobel J, Nyirjesy P, Schodel F, et al.
Clin Infect Dis
. 2018 Apr;
66(12):1928-1936.
PMID: 29697768
Background: Recurrent vulvovaginal candidiasis (RVVC) is a problematic form of mucosal Candida infection, characterized by repeated episodes per year. Candida albicans is the most common cause of RVVC. Currently, there...