Ashish Dhir
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Explore the profile of Ashish Dhir including associated specialties, affiliations and a list of published articles.
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86
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2680
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Recent Articles
1.
Andrew P, MacMahon J, Liu X, Saito N, Berger K, Morgan J, et al.
CNS Neurosci Ther
. 2025 Mar;
31(3):e70215.
PMID: 40022508
Aims: Humans and animals acutely intoxicated with the organophosphate soman can develop sustained status epilepticus (SE) that rapidly becomes refractory to benzodiazepines. We compared the antiseizure efficacy of midazolam, a...
2.
Lepelley A, Mina E, Van Nieuwenhove E, Waumans L, Fraitag S, Rice G, et al.
J Exp Med
. 2021 Aug;
218(10).
PMID: 34387651
Mitochondrial DNA (mtDNA) has been suggested to drive immune system activation, but the induction of interferon signaling by mtDNA has not been demonstrated in a Mendelian mitochondrial disease. We initially...
3.
Zolkowska D, Dhir A, Rogawski M
Arch Toxicol
. 2021 Apr;
95(7):2459-2468.
PMID: 33914090
Tetramethylenedisulfotetramine (TETS), a noncompetitive GABA receptor antagonist, is a potent, highly lethal convulsant that is considered to be a chemical threat agent. Here, we assessed the ability of the AMPA...
4.
Uggenti C, Lepelley A, Depp M, Badrock A, Rodero M, El-Daher M, et al.
Nat Genet
. 2020 Nov;
52(12):1364-1372.
PMID: 33230297
Inappropriate stimulation or defective negative regulation of the type I interferon response can lead to autoinflammation. In genetically uncharacterized cases of the type I interferonopathy Aicardi-Goutières syndrome, we identified biallelic...
5.
Dhir A, Bruun D, Guignet M, Tsai Y, Gonzalez E, Calsbeek J, et al.
Ann N Y Acad Sci
. 2020 Sep;
1480(1):183-206.
PMID: 32915470
Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous high-amplitude...
6.
Gonzalez E, Rindy A, Guignet M, Calsbeek J, Bruun D, Dhir A, et al.
Arch Toxicol
. 2020 Apr;
94(6):2149-2162.
PMID: 32303805
Organophosphate (OP) threat agents can trigger seizures that progress to status epilepticus, resulting in persistent neuropathology and cognitive deficits in humans and preclinical models. However, it remains unclear whether patients...
7.
Singh S, Ahmed D, Dolatshad H, Tatwavedi D, Schulze U, Sanchi A, et al.
Leukemia
. 2020 Feb;
34(9):2525-2530.
PMID: 32076118
No abstract available.
8.
Dhir A
Phytother Res
. 2020 Feb;
34(6):1268-1281.
PMID: 32061189
Natural polyphenols are being tested both in preclinical and clinical settings for the treatment of different neurological disorders. The article describes the outcome of three polyphenols, resveratrol, epigallocatechin gallate, and...
9.
Pajak A, Laine I, Clemente P, El-Fissi N, Schober F, Maffezzini C, et al.
PLoS Genet
. 2019 Aug;
15(7):e1008240.
PMID: 31365523
The RNA helicase SUV3 and the polynucleotide phosphorylase PNPase are involved in the degradation of mitochondrial mRNAs but their roles in vivo are not fully understood. Additionally, upstream processes, such...
10.
Guignet M, Dhakal K, Flannery B, Hobson B, Zolkowska D, Dhir A, et al.
Neurobiol Dis
. 2019 Mar;
133:104431.
PMID: 30905768
Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an urgent need for improved therapies. Rat models of acute intoxication...