Kiran Kumar Akula
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Explore the profile of Kiran Kumar Akula including associated specialties, affiliations and a list of published articles.
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12
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136
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Recent Articles
1.
Akula K, Kulkarni S
Phytother Res
. 2013 Jul;
28(5):714-21.
PMID: 23893477
Curcumin, obtained from Curcuma longa, has been in use for manifold human disorders. The present study explores the effect of curcumin against pentylenetetrazol (PTZ) seizure threshold in mice. The possible...
2.
Kulkarni S, Akula K, Deshpande J
Pharmacology
. 2012 Feb;
89(1-2):83-90.
PMID: 22343362
Background: Curcumin is the active principle of Curcuma longa, one of the widely used components in the traditional system of medicine in India. Despite its efficacy in experimental studies aiming...
3.
Kulkarni S, Dhir A, Akula K
ScientificWorldJournal
. 2009 Nov;
9:1233-41.
PMID: 19882093
Major depression, a debilitating psychiatric disorder, is predicted to be the second most prevalent human illness by the year 2020. Various antidepressants, ranging from monoamine oxidase inhibitors to recently developed...
4.
Akula K, Kaur M, Bishnoi M, Kulkarni S
J Sep Sci
. 2008 Sep;
31(18):3139-47.
PMID: 18780378
A new, rapid and sensitive RP-HPLC method with UV spectrophotometric detection was developed and validated for the concomitant estimation of adenosine and related purines in rat brain tissue preparations. The...
5.
Akula K, Kaur M, Kulkarni S
J Chromatogr A
. 2008 Sep;
1209(1-2):230-7.
PMID: 18778824
A new, rapid and sensitive high-performance thin-layer chromatographic (HPTLC) method with densitometry was developed and validated for the concomitant estimation of purines like adenosine (Ade) and its major metabolites, inosine...
6.
Kulkarni S, Akula K, Dhir A
Indian J Exp Biol
. 2008 Aug;
46(6):465-9.
PMID: 18697606
Withania somnifera (ashwagandha) is a widely used herb in the Ayurvedic system of medicine. The objective of the present study was to elucidate the effect of W. somnifera root extract...
7.
Akula K, Dhir A, Kulkarni S
Eur J Pharmacol
. 2008 May;
587(1-3):129-34.
PMID: 18457833
The present study was performed to examine the involvement of nitric oxide (NO) signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol seizure threshold in mice. Minimal dose of...
8.
Dhir A, Akula K, Kulkarni S
Prog Neuropsychopharmacol Biol Psychiatry
. 2008 Feb;
32(3):835-43.
PMID: 18234412
Huntington's disease is an incurable, adult-onset, dominantly inherited neurodegenerative disease. The clinical symptoms of the disease are primarily related to the progressive death of medium spiny gamma-amino butyric acid (GABAergic)...
9.
Akula K, Dhir A, Kulkarni S
Epilepsy Res
. 2007 Dec;
78(1):60-70.
PMID: 18054463
Multiple lines of investigations have explored the role of cyclooxygenases (COX) in epilepsy and related neuropsychiatric disorders. Cyclooxygenase particularly, COX-2 expression was found to increase in brain during seizure paradigms....
10.
Akula K, Dhir A, Kulkarni S
Fundam Clin Pharmacol
. 2007 Nov;
21(6):583-94.
PMID: 18034659
Adenosine is one of the inhibitory neuromodulators in the brain and is considered to be responsible for seizure arrest and postictal refractoriness. Adenosine, adenosine receptor agonists, and adenosine uptake blockers...