Arun Kalliat Thazhathveetil
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Explore the profile of Arun Kalliat Thazhathveetil including associated specialties, affiliations and a list of published articles.
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8
Citations
255
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Recent Articles
1.
Bellani M, Huang J, Zhang J, Gali H, Thazhathveetil A, Pokharel D, et al.
DNA Repair (Amst)
. 2023 Jun;
128:103525.
PMID: 37320956
Immunofluorescence imaging is a standard experimental tool for monitoring the response of cellular factors to DNA damage. Visualizing the recruitment of DNA Damage Response (DDR) components requires high affinity antibodies,...
2.
Thazhathveetil A, Trifonov A, Wasielewski M, Lewis F
J Phys Chem A
. 2014 Jun;
118(45):10359-63.
PMID: 24912084
The effect of Mg(2+) cations on the electronic spectra and dynamics and efficiency of hole transport has been determined by means of femtosecond time-resolved transient absorption spectroscopy for DNA hairpins...
3.
Alam R, Thazhathveetil A, Li H, Seidman M
Methods Mol Biol
. 2014 Feb;
1114:103-13.
PMID: 24557899
Strategies for site-specific modulation of genomic sequences in mammalian cells require two components. One must be capable of recognizing and activating a specific target sequence in vivo, driving that site...
4.
Huang J, Liu S, Bellani M, Thazhathveetil A, Ling C, de Winter J, et al.
Mol Cell
. 2013 Nov;
52(3):434-46.
PMID: 24207054
The replicative machinery encounters many impediments, some of which can be overcome by lesion bypass or replication restart pathways, leaving repair for a later time. However, interstrand crosslinks (ICLs), which...
5.
Muniandy P, Thapa D, Thazhathveetil A, Liu S, Seidman M
J Biol Chem
. 2009 Aug;
284(41):27908-27917.
PMID: 19684342
Interstrand cross-links (ICLs) are absolute blocks to transcription and replication and can provoke genomic instability and cell death. Studies in bacteria define a two-stage repair scheme, the first involving recognition...
6.
Wu Y, Rawtani N, Thazhathveetil A, Kenny M, Seidman M, Brosh Jr R
Biochemistry
. 2008 Apr;
47(18):5068-77.
PMID: 18410127
Alternate DNA structures other than double-stranded B-form DNA can potentially impede cellular processes such as transcription and replication. The DNA triplex helix and G4 tetraplex structures that form by Hoogsteen...
7.
Alam M, Majumdar A, Thazhathveetil A, Liu S, Liu J, Puri N, et al.
Biochemistry
. 2007 Aug;
46(35):10222-33.
PMID: 17691818
We are developing triple helix forming oligonucleotides (TFOs) for gene targeting. Previously, we synthesized bioactive TFOs containing 2'-O-methylribose (2'-OMe) and 2'-O-aminoethylribose (2'-AE) residues. Active TFOs contained four contiguous 2'-AE residues...
8.
Thazhathveetil A, Liu S, Indig F, Seidman M
Bioconjug Chem
. 2007 Mar;
18(2):431-7.
PMID: 17373769
DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understood. Laser confocal...