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My Mansueto

Explore the profile of My Mansueto including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 27
Followers 0
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Recent Articles
1.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
Bioorg Med Chem Lett . 2020 Aug; 30(17):127390. PMID: 32738973
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...
2.
Babu Boga S, Alhassan A, Liu J, Guiadeen D, Krikorian A, Gao X, et al.
Bioorg Med Chem Lett . 2017 Jul; 27(16):3939-3943. PMID: 28720503
8-Amino-imidazo[1,5-a]pyrazine-based Bruton's tyrosine kinase (BTK) inhibitors, such as 6, exhibited potent inhibition of BTK but required improvements in both kinase and hERG selectivity (Liu et al., 2016; Gao et al.,...
3.
Gao X, Wang J, Liu J, Guiadeen D, Krikorian A, Babu Boga S, et al.
Bioorg Med Chem Lett . 2017 Mar; 27(6):1471-1477. PMID: 28254166
We report the design and synthesis of a series of novel Bruton's Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket. This series of compounds has...
4.
Lim J, Kelley E, Methot J, Zhou H, Petrocchi A, Chen H, et al.
J Med Chem . 2016 Jun; 59(13):6501-11. PMID: 27329786
The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. Specific BRAF and MEK inhibitors have...
5.
Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Babu Boga S, et al.
ACS Med Chem Lett . 2016 Mar; 7(2):198-203. PMID: 26985298
Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B...