Arnon Rosenthal
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Explore the profile of Arnon Rosenthal including associated specialties, affiliations and a list of published articles.
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34
Citations
3641
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Recent Articles
1.
Long H, Simmons A, Mayorga A, Burgess B, Nguyen T, Budda B, et al.
Alzheimers Res Ther
. 2024 Oct;
16(1):235.
PMID: 39444037
Background: Variants of the gene triggering receptor expressed on myeloid cells-2 (TREM2) increase the risk of Alzheimer's disease (AD) and other neurodegenerative disorders. Signaling by TREM2, an innate immune receptor...
2.
Ward M, Carter L, Huang J, Maslyar D, Budda B, Paul R, et al.
Alzheimers Dement (N Y)
. 2024 Feb;
10(1):e12452.
PMID: 38356474
Introduction: Heterozygous mutations in the gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance. Latozinemab...
3.
Boylan M, Pincetic A, Romano G, Tatton N, Kenkare-Mitra S, Rosenthal A
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958929
Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration designed to address immune surveillance failure in the brain. Microglia, as central nervous system (CNS)-resident myeloid cells, routinely perform surveillance...
4.
Kurnellas M, Mitra A, Schwabe T, Paul R, Arrant A, Roberson E, et al.
J Transl Med
. 2023 Jun;
21(1):387.
PMID: 37322482
Background: Heterozygous loss-of-function mutations in the progranulin (PGRN) gene (GRN) cause a reduction in PGRN and lead to the development of frontotemporal dementia (FTD-GRN). PGRN is a secreted lysosomal chaperone,...
5.
Yang J, Deresa I, Ho W, Long H, Maslyar D, Rosenthal A, et al.
J Immunol
. 2022 Dec;
210(2):204-215.
PMID: 36480261
Antagonizing the CD47-signal regulatory protein (SIRP)α pathway, a critical myeloid checkpoint, promotes antitumor immunity. In this study, we describe the development of AL008, a pan-allelic, SIRPα-specific Ab that triggers the...
6.
Lambris J, Rosenthal A, Pelegrin P, Tremblay M, Chen P
Trends Pharmacol Sci
. 2022 Jul;
43(8):611-614.
PMID: 35839748
No abstract available.
7.
Rhinn H, Tatton N, McCaughey S, Kurnellas M, Rosenthal A
Trends Pharmacol Sci
. 2022 Jan;
43(8):641-652.
PMID: 35039149
Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain. It regulates lysosomal biogenesis,...
8.
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al.
Acta Neuropathol
. 2020 Aug;
140(4):513-534.
PMID: 32772264
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in...
9.
Wang S, Mustafa M, Yuede C, Salazar S, Kong P, Long H, et al.
J Exp Med
. 2020 Jun;
217(9).
PMID: 32579671
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of amyloid β...
10.
Hong S, Beja-Glasser V, Nfonoyim B, Frouin A, Li S, Ramakrishnan S, et al.
Science
. 2016 Apr;
352(6286):712-716.
PMID: 27033548
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in...