Arlene L Young
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Explore the profile of Arlene L Young including associated specialties, affiliations and a list of published articles.
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2
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Recent Articles
1.
Eccles W, Blevitt J, Booker J, Chrovian C, Crawford S, de Leon A, et al.
Bioorg Med Chem Lett
. 2012 Dec;
23(3):811-5.
PMID: 23260350
Leukotrienes (LT's) are known to play a physiological role in inflammatory immune response. Leukotriene A(4) hydrolase (LTA(4)H) is a cystolic enzyme that stereospecifically catalyzes the transformation of LTA(4) to LTB(4)....
2.
Tanis V, Bacani G, Blevitt J, Chrovian C, Crawford S, De Leon A, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7504-11.
PMID: 23127888
Previously, benzthiazole containing LTA(4)H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering...