Arjun Bhutkar
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Explore the profile of Arjun Bhutkar including associated specialties, affiliations and a list of published articles.
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60
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6385
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Recent Articles
1.
Peinado P, Stazi M, Ballabio C, Margineanu M, Li Z, Colon C, et al.
Nature
. 2025 Feb;
PMID: 39939778
Elevated or ectopic expression of neuronal receptors promotes tumour progression in many cancer types; neuroendocrine (NE) transformation of adenocarcinomas has also been associated with increased aggressiveness. Whether the defining neuronal...
2.
Westcott P, Muyas F, Hauck H, Smith O, Sacks N, Ely Z, et al.
Nat Genet
. 2023 Sep;
55(10):1686-1695.
PMID: 37709863
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most MMRd tumors do not durably respond...
3.
Naranjo S, Cabana C, LaFave L, Romero R, Shanahan S, Bhutkar A, et al.
Genes Dev
. 2022 Sep;
36(15-16):936-949.
PMID: 36175034
Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While existing genetically engineered mouse models...
4.
Pitter K, Grbovic-Huezo O, Joost S, Singhal A, Blum M, Wu K, et al.
Cancer Res
. 2022 Aug;
82(19):3549-3560.
PMID: 35952360
Significance: This work provides important insights into how different model systems of pancreatic ductal adenocarcinoma mold the phenotypic space of cancer cells, highlighting the power of in vivo models.
5.
Romero R, Sanchez-Rivera F, Westcott P, Mercer K, Bhutkar A, Muir A, et al.
Nat Cancer
. 2022 Feb;
1(9):935.
PMID: 35121957
No abstract available.
6.
Patel R, Romero R, Watson E, Liang A, Burger M, Westcott P, et al.
Nat Commun
. 2022 Jan;
13(1):256.
PMID: 35017504
The GATA4 transcription factor acts as a master regulator of development of multiple tissues. GATA4 also acts in a distinct capacity to control a stress-inducible pro-inflammatory secretory program that is...
7.
Duong E, Fessenden T, Lutz E, Dinter T, Yim L, Blatt S, et al.
Immunity
. 2021 Nov;
55(2):308-323.e9.
PMID: 34800368
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing...
8.
Wilson M, Callens C, Le Gallo M, Mironov S, Ding Q, Salamagnon A, et al.
Sci Adv
. 2021 Oct;
7(44):eabf6063.
PMID: 34705506
The epithelial-mesenchymal transition (EMT) and primary ciliogenesis induce stem cell properties in basal mammary stem cells (MaSCs) to promote mammogenesis, but the underlying mechanisms remain incompletely understood. Here, we show...
9.
Concepcion C, Ma S, LaFave L, Bhutkar A, Liu M, DeAngelo L, et al.
Cancer Discov
. 2021 Sep;
12(2):562-585.
PMID: 34561242
/ encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of mutation...
10.
Burger M, Cruz A, Crossland G, Gaglia G, Ritch C, Blatt S, et al.
Cell
. 2021 Sep;
184(19):4996-5014.e26.
PMID: 34534464
CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In...