Aram Chang
Overview
Explore the profile of Aram Chang including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
254
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Recent Articles
1.
Chang A, Liu J, Nguyen K, Kumar P
Protein Expr Purif
. 2022 Jun;
198:106129.
PMID: 35752385
N-methyl-d-aspartate (NMDA) receptors are hetero-tetrameric ion channels typically consisting of two GluN1 and two GluN2 subunits. A GluN2D subunit containing NMDA receptor dysfunction has been implicated in several neurological diseases,...
2.
Chang A, Abderemane-Ali F, Hura G, Rossen N, Gate R, Minor Jr D
Neuron
. 2018 Feb;
97(4):836-852.e6.
PMID: 29429937
Kv7 (KCNQ) voltage-gated potassium channels control excitability in the brain, heart, and ear. Calmodulin (CaM) is crucial for Kv7 function, but how this calcium sensor affects activity has remained unclear....
3.
Lomax J, Bianchetti C, Chang A, Phillips Jr G, Fox B, Raines R
J Mol Biol
. 2014 Jun;
426(17):3041-56.
PMID: 24941155
Ribonuclease inhibitor (RI) is a conserved protein of the mammalian cytosol. RI binds with high affinity to diverse secretory ribonucleases (RNases) and inhibits their enzymatic activity. Although secretory RNases are...
4.
Singh S, Chang A, Helmich K, Bingman C, Wrobel R, Beebe E, et al.
ACS Chem Biol
. 2013 May;
8(7):1632-9.
PMID: 23662776
Sugar methyltransferases (MTs) are an important class of tailoring enzymes that catalyze the transfer of a methyl group from S-adenosyl-l-methionine to sugar-based N-, C- and O-nucleophiles. While sugar N- and...
5.
Xu Q, Chang A, Tolia A, Minor Jr D
J Mol Biol
. 2012 Nov;
425(2):378-94.
PMID: 23178170
Calmodulin (CaM) is an important regulator of Kv7.x (KCNQx) voltage-gated potassium channels. Channels from this family produce neuronal M currents and cardiac and auditory I(KS) currents and harbor mutations that...
6.
Chang A, Singh S, Helmich K, Goff R, Bingman C, Thorson J, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(43):17649-54.
PMID: 21987796
Glycosyltransferases are useful synthetic catalysts for generating natural products with sugar moieties. Although several natural product glycosyltransferase structures have been reported, design principles of glycosyltransferase engineering for the generation of...
7.
Chang A, Singh S, Phillips Jr G, Thorson J
Curr Opin Biotechnol
. 2011 May;
22(6):800-8.
PMID: 21592771
Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention...
8.
Singh S, Chang A, Goff R, Bingman C, Gruschow S, Sherman D, et al.
Proteins
. 2011 May;
79(7):2181-8.
PMID: 21538548
Mitomycins are quinone-containing antibiotics, widely used as antitumor drugs in chemotherapy. Mitomycin-7-O-methyltransferase (MmcR), a key tailoring enzyme involved in the biosynthesis of mitomycin in Streptomyces lavendulae, catalyzes the 7-O-methylation of...
9.
Chang A, Singh S, Bingman C, Thorson J, Phillips Jr G
Acta Crystallogr D Biol Crystallogr
. 2011 Mar;
67(Pt 3):197-203.
PMID: 21358050
The X-ray structure determination at 2.4 Å resolution of the putative orsellinic acid C3 O-methyltransferase (CalO1) involved in calicheamicin biosynthesis is reported. Comparison of CalO1 with a homology model of...
10.
Moretti R, Chang A, Peltier-Pain P, Bingman C, Phillips Jr G, Thorson J
J Biol Chem
. 2011 Feb;
286(15):13235-43.
PMID: 21317292
Directed evolution is a valuable technique to improve enzyme activity in the absence of a priori structural knowledge, which can be typically enhanced via structure-guided strategies. In this study, a...