April L Darling
Overview
Explore the profile of April L Darling including associated specialties, affiliations and a list of published articles.
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21
Citations
1788
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Recent Articles
1.
Hill S, Beaulieu-Abdelahad D, Lemus A, Webster J, Ospina S, Darling A, et al.
ACS Chem Biol
. 2023 May;
18(5):1124-1135.
PMID: 37144894
The accumulation and aggregation of the microtubule-associated protein tau (tau) into intracellular neuronal tangles are a hallmark of a range of progressive neurodegenerative tauopathies, including Alzheimer's disease (AD), frontotemporal dementia,...
2.
Criado-Marrero M, Blazier D, Gould L, Gebru N, Ospina S, Armendariz D, et al.
Sci Rep
. 2022 May;
12(1):7372.
PMID: 35513476
Tau accumulation and progressive loss of neurons are associated with Alzheimer's disease (AD). Aggregation of tau has been associated with endoplasmic reticulum (ER) stress and the activation of the unfolded...
3.
Darling A, Dahrendorff J, Creodore S, Dickey C, Blair L, Uversky V
Protein Sci
. 2021 Mar;
30(7):1350-1359.
PMID: 33686711
Alzheimer's disease is a progressive fatal neurodegenerative disease with no cure or effective treatments. The hallmarks of disease include extracellular plaques and intracellular tangles of aggregated protein. The intracellular tangles...
4.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
5.
Sandusky-Beltran L, Kovalenko A, Placides D, Ratnasamy K, Ma C, Hunt Jr J, et al.
J Clin Invest
. 2021 Feb;
131(4).
PMID: 33586680
Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction...
6.
Darling A, Shorter J
Biochim Biophys Acta Mol Cell Res
. 2021 Feb;
1868(5):118984.
PMID: 33549703
Protein aggregation is a hallmark of neurodegenerative diseases. However, the mechanism that induces pathogenic aggregation is not well understood. Recently, it has emerged that several of the pathological proteins found...
7.
Darling A, Shorter J
Trends Neurosci
. 2020 Aug;
43(10):740-743.
PMID: 32792144
Amyloid-β (Aβ) accumulation in the brain is a cardinal event in Alzheimer's disease (AD), but the structural basis of Aβ-elicited neurotoxicity is unknown. In a recent paper, Ciudad et al....
8.
Webster J, Darling A, Sanders T, Blazier D, Vidal-Aguiar Y, Beaulieu-Abdelahad D, et al.
Int J Mol Sci
. 2020 Aug;
21(15).
PMID: 32751642
Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these...
9.
Webster J, Darling A, Uversky V, Blair L
Front Pharmacol
. 2019 Oct;
10:1047.
PMID: 31619995
Misfolding, aggregation, and aberrant accumulation of proteins are central components in the progression of neurodegenerative disease. Cellular molecular chaperone systems modulate proteostasis, and, therefore, are primed to influence aberrant protein-induced...
10.
Fonin A, Darling A, Kuznetsova I, Turoverov K, Uversky V
Cell Mol Life Sci
. 2019 Aug;
76(22):4461-4492.
PMID: 31428838
GPCR-G protein signaling system recognizes a multitude of extracellular ligands and triggers a variety of intracellular signaling cascades in response. In humans, this system includes more than 800 various GPCRs...