Antonio M Estevez
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Explore the profile of Antonio M Estevez including associated specialties, affiliations and a list of published articles.
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24
Citations
483
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Recent Articles
1.
Ceballos-Perez G, Rico-Jimenez M, Gomez-Linan C, Estevez A
Parasit Vectors
. 2023 Apr;
16(1):118.
PMID: 37004055
Background: Trypanosomes are single-celled eukaryotes that rely heavily on post-transcriptional mechanisms to regulate gene expression. RNA-binding proteins play essential roles in regulating the fate, abundance and translation of messenger RNAs...
2.
Gomez-Linan C, Gomez-Diaz E, Ceballos-Perez G, Fernandez-Moya S, Estevez A
Nucleic Acids Res
. 2022 Dec;
50(21):12251-12265.
PMID: 36454008
In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts...
3.
Guegan F, Rajan K, Bento F, Pinto-Neves D, Sequeira M, Guminska N, et al.
Sci Adv
. 2022 Jun;
8(24):eabn2706.
PMID: 35704590
The parasite causes African sleeping sickness that is fatal to patients if untreated. Parasite differentiation from a replicative slender form into a quiescent stumpy form promotes host survival and parasite...
4.
Rico-Jimenez M, Ceballos-Perez G, Gomez-Linan C, Estevez A
Nucleic Acids Res
. 2021 Mar;
49(7):3814-3825.
PMID: 33744953
Post-transcriptional regulation of gene expression is particularly important in trypanosomatid protozoa. RNA-binding proteins (RBPs) regulate mRNA stability and translation, yet information about how RBPs are able to link environmental cues...
5.
Garcia-Caballero D, Perez-Moreno G, Estevez A, Ruiz-Perez L, Vidal A, Gonzalez-Pacanowska D
Sci Rep
. 2017 Aug;
7(1):8505.
PMID: 28819113
Inosine may arise in DNA as a result of oxidative deamination of adenine or misincorporation of deoxyinosine triphosphate during replication. On the other hand, the occurrence of inosine in RNA...
6.
Cabello-Donayre M, Malagarie-Cazenave S, Campos-Salinas J, Galvez F, Rodriguez-Martinez A, Pineda-Molina E, et al.
Mol Microbiol
. 2016 Jun;
101(6):895-908.
PMID: 27328668
Pathogenic trypanosomatid parasites are auxotrophic for heme and they must scavenge it from their human host. Trypanosoma brucei (responsible for sleeping sickness) and Leishmania (leishmaniasis) can fulfill heme requirement by...
7.
Das A, Bellofatto V, Rosenfeld J, Carrington M, Romero-Zaliz R, Del Val C, et al.
Mol Biochem Parasitol
. 2015 Mar;
199(1-2):1-4.
PMID: 25725478
Trypanosomes are early-branched eukaryotes that show an unusual dependence on post-transcriptional mechanisms to regulate gene expression. RNA-binding proteins are crucial in controlling mRNA fate in these organisms, but their RNA...
8.
Fernandez-Moya S, Carrington M, Estevez A
PLoS One
. 2014 Sep;
9(9):e107608.
PMID: 25215501
We have characterized the RNA-binding protein RBP33 in Trypanosoma brucei, and found that it localizes to the nucleus and is essential for viability. The subset of RNAs bound to RBP33...
9.
Fernandez-Moya S, Carrington M, Estevez A
Nucleic Acids Res
. 2014 May;
42(11):7201-9.
PMID: 24813448
We have compared the transcriptomes of cultured procyclic Trypanosoma brucei cells in early and late logarithmic phases and found that ∼200 mRNAs were differentially regulated. In late log phase cells,...
10.
Fernandez-Moya S, Garcia-Perez A, Kramer S, Carrington M, Estevez A
PLoS One
. 2012 Nov;
7(11):e48870.
PMID: 23145003
Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. Regulation is exerted through the action of...