Anthony Tubbs
Overview
Explore the profile of Anthony Tubbs including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1438
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Recent Articles
1.
Chen B, Wang Y, Tubbs A, Zong D, Fowler F, Zolnerowich N, et al.
Elife
. 2021 Sep;
10.
PMID: 34477552
DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G- phases of the cell cycle in part due to 53BP1 antagonizing...
2.
van Wietmarschen N, Sridharan S, Nathan W, Tubbs A, Chan E, Callen E, et al.
Nature
. 2020 Oct;
586(7828):292-298.
PMID: 32999459
The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of...
3.
He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(33):20100-20108.
PMID: 32727902
Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a severe immunodeficiency syndrome, but the nature of the defect remains unknown. We assessed here the role of Lsh in hematopoiesis...
4.
Feng X, Tubbs A, Zhang C, Tang M, Sridharan S, Wang C, et al.
EMBO J
. 2020 Jun;
39(14):e104036.
PMID: 32484965
Mechanistic understanding of how ionizing radiation induces type I interferon signaling and how to amplify this signaling module should help to maximize the efficacy of radiotherapy. In the current study,...
5.
Braun R, Anthuber L, Hirsch D, Wangsa D, Lack J, McNeil N, et al.
Clin Cancer Res
. 2020 Apr;
26(13):3468-3480.
PMID: 32253233
Purpose: The standard treatment of patients with locally advanced rectal cancer consists of preoperative chemoradiotherapy (CRT) followed by surgery. However, the response of individual tumors to CRT is extremely diverse,...
6.
Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, et al.
Cell
. 2018 Aug;
174(5):1127-1142.e19.
PMID: 30078706
Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal instability. However, the defining genomic features of replication origins and fragile sites are among the least understood...
7.
Skau C, Fischer R, Gurel P, Thiam H, Tubbs A, Baird M, et al.
Cell
. 2018 Apr;
173(2):529.
PMID: 29625058
No abstract available.
8.
Tubbs A, Nussenzweig A
Cell
. 2017 Feb;
168(4):644-656.
PMID: 28187286
Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the...
9.
Skau C, Fischer R, Gurel P, Thiam H, Tubbs A, Baird M, et al.
Cell
. 2016 Nov;
167(6):1571-1585.e18.
PMID: 27839864
Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus...
10.
Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton M, Tubbs A, et al.
Sci Signal
. 2016 Sep;
9(445):ra91.
PMID: 27625305
Among the various subtypes of acute myeloid leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic...