Anthony E Boitano
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Explore the profile of Anthony E Boitano including associated specialties, affiliations and a list of published articles.
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22
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1228
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Recent Articles
1.
Gustafsson K, Rhee C, Frodermann V, Scadden E, Li D, Iwamoto Y, et al.
Blood Adv
. 2023 Sep;
7(22):6964-6973.
PMID: 37748049
Tissue-resident myeloid (TRM) cells in adults have highly variable lifespans, and may be derived from early embryonic yolk sac, fetal liver, or bone marrow. Some of these TRM cells are...
2.
Gustafsson K, Rhee C, Frodermann V, Scadden E, Li D, Iwamoto Y, et al.
bioRxiv
. 2023 Sep;
PMID: 37732224
Tissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are...
3.
Srikanthan M, Humbert O, Haworth K, Ironside C, Rajawat Y, Blazar B, et al.
Mol Ther Methods Clin Dev
. 2020 Apr;
17:455-464.
PMID: 32226796
Conditioning chemotherapy is used to deplete hematopoietic stem cells in the recipient's marrow, facilitating donor cell engraftment. Although effective, a major issue with chemotherapy is the systemic genotoxicity that increases...
4.
Ting P, Parker A, Lee J, Trussell C, Sharif O, Luna F, et al.
Nat Methods
. 2018 Oct;
15(11):941-946.
PMID: 30297964
CRISPR-Cas9 screening allows genome-wide interrogation of gene function. Currently, to achieve the high and uniform Cas9 expression desirable for screening, one needs to engineer stable and clonal Cas9-expressing cells-an approach...
5.
A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery
Joslin J, Gilligan J, Anderson P, Garcia C, Sharif O, Hampton J, et al.
SLAS Discov
. 2018 May;
23(7):697-707.
PMID: 29843542
The goal of high-throughput screening is to enable screening of compound libraries in an automated manner to identify quality starting points for optimization. This often involves screening a large diversity...
6.
Wagner Jr J, Brunstein C, Boitano A, DeFor T, McKenna D, Sumstad D, et al.
Cell Stem Cell
. 2015 Dec;
18(1):144-55.
PMID: 26669897
Clinical application of umbilical cord blood (UCB) as a source of hematopoietic stem cells for transplantation is limited by low CD34+ cell dose, increased risk of graft failure, and slow...
7.
Lund T, Boitano A, Delaney C, Shpall E, Wagner J
Nat Rev Clin Oncol
. 2014 Dec;
12(3):163-74.
PMID: 25511187
The use of umbilical cord blood (UCB) as an alternative haematopoietic cell source in lieu of bone marrow for haematopoietic reconstitution is increasingly becoming a mainstay treatment for both malignant...
8.
de Lichtervelde L, Boitano A, Wang Y, Krastel P, Petersen F, Cooke M, et al.
ACS Chem Biol
. 2013 Feb;
8(5):866-70.
PMID: 23441826
Hematopoietic stem cells (HSCs) are the progenitor cells that give rise to all blood cells. The ability to control HSC differentiation has the potential to improve the success of bone...
9.
de Lichtervelde L, Antal C, Boitano A, Wang Y, Krastel P, Petersen F, et al.
Chem Biol
. 2012 Aug;
19(8):994-1000.
PMID: 22921066
To identify small molecules that selectively control hematopoietic stem cell differentiation, we performed an unbiased screen using primary human CD34(+) cells. We identified a plant-derived natural product, euphohelioscopin A, capable...
10.
Boitano A, de Lichtervelde L, Snead J, Cooke M, Schultz P
Proc Natl Acad Sci U S A
. 2012 Aug;
109(35):14019-23.
PMID: 22891346
Molecules that control the lineage commitment of hematopoietic stem cells (HSCs) may allow the expansion of enriched progenitor populations for both research and therapeutic uses. In an effort to better...