Hans-Peter Buchstaller
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Explore the profile of Hans-Peter Buchstaller including associated specialties, affiliations and a list of published articles.
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19
Citations
299
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Recent Articles
1.
Rusinko A, Rezaei M, Friedrich L, Buchstaller H, Kuhn D, Ghogare A
J Chem Inf Model
. 2023 Dec;
64(1):3-8.
PMID: 38134123
The widespread proliferation of artificial intelligence (AI) and machine learning (ML) methods has a profound effect on the drug discovery process. However, many scientists are reluctant to utilize these powerful...
2.
Buchstaller H, Sala-Hojman A, Leiendecker M, Albers J, Anlauf U, Berges N, et al.
J Med Chem
. 2023 Jul;
66(13):8666-8686.
PMID: 37403966
Hypoxia-inducible factors (HIFs) are heterodimeric transcription factors induced in diverse pathophysiological settings. Inhibition of HIF-2α has become a strategy for cancer treatment since the discovery that small molecules, upon binding...
3.
Blum A, Dorsch D, LInde N, Brandstetter S, Buchstaller H, Busch M, et al.
J Med Chem
. 2023 Feb;
66(4):2386-2395.
PMID: 36728508
The treatment of gastrointestinal stromal tumors (GISTs) driven by activating mutations in the gene is a prime example of targeted therapy for treatment of cancer. The approval of the tyrosine...
4.
Buchstaller H, Anlauf U, Dorsch D, Kogler S, Kuhn D, Lehmann M, et al.
J Med Chem
. 2021 Jul;
64(14):10371-10392.
PMID: 34255518
Constitutive activation of the canonical Wnt signaling pathway, in most cases driven by inactivation of the tumor suppressor APC, is a hallmark of colorectal cancer. Tankyrases are druggable key regulators...
5.
Schindler C, Baumann H, Blum A, Bose D, Buchstaller H, Burgdorf L, et al.
J Chem Inf Model
. 2020 Aug;
60(11):5457-5474.
PMID: 32813975
Accurate ranking of compounds with regards to their binding affinity to a protein using computational methods is of great interest to pharmaceutical research. Physics-based free energy calculations are regarded as...
6.
Badder L, Hollins A, Herpers B, Yan K, Ewan K, Thomas M, et al.
PLoS One
. 2020 Aug;
15(8):e0235319.
PMID: 32810173
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the...
7.
Buchstaller H, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, et al.
J Med Chem
. 2019 Aug;
62(17):7897-7909.
PMID: 31381853
Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological targets that recently gained interest for anticancer therapy in Wnt pathway dependent tumors. 2-Aryl-quinazolinones were identified and optimized into potent tankyrase inhibitors...
8.
Menon M, Elliott R, Bowers L, Balan N, Rafiq R, Costa-Cabral S, et al.
Sci Rep
. 2019 Jan;
9(1):201.
PMID: 30655555
Inhibition of the PARP superfamily tankyrase enzymes suppresses Wnt/β-catenin signalling in tumour cells. Here, we describe here a novel, drug-like small molecule inhibitor of tankyrase MSC2504877 that inhibits the growth...
9.
Kokh D, Amaral M, Bomke J, Gradler U, Musil D, Buchstaller H, et al.
J Chem Theory Comput
. 2018 May;
14(7):3859-3869.
PMID: 29768913
Drug-target residence time (τ), one of the main determinants of drug efficacy, remains highly challenging to predict computationally and, therefore, is usually not considered in the early stages of drug...
10.
Schuetz D, Richter L, Amaral M, Grandits M, Gradler U, Musil D, et al.
J Med Chem
. 2018 Apr;
61(10):4397-4411.
PMID: 29701469
Residence time and more recently the association rate constant k are increasingly acknowledged as important parameters for in vivo efficacy and safety of drugs. However, their broader consideration in drug...