Anneroos E Nederstigt
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Explore the profile of Anneroos E Nederstigt including associated specialties, affiliations and a list of published articles.
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4
Citations
13
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Recent Articles
1.
van Bergen W, Nederstigt A, Heck A, Baggelaar M
Mol Cell Proteomics
. 2025 Jan;
24(2):100906.
PMID: 39826875
Protein kinases are prime targets for drug development due to their involvement in various cancers. However, selective inhibition of kinases, while avoiding off-target effects remains a significant challenge for the...
2.
Bukhari Z, Gu L, Nederstigt A, Cope L, Bolhuis D, Harvey K, et al.
bioRxiv
. 2024 Sep;
PMID: 39282319
Ubiquitin (Ub) is a post-translational modification that largely controls proteostasis through mechanisms spanning transcription, translation, and notably, protein degradation. Ub conjugation occurs through a hierarchical cascade of three enzyme classes...
3.
Irshad B, Lu C, Nederstigt A, Hu P, Xue L, Lin-Cereghino J, et al.
Protein Expr Purif
. 2023 Aug;
212:106355.
PMID: 37598731
Pichia pastoris, a methylotrophic yeast used for recombinant protein expression, has the capability of performing many eukaryotic post-translational modifications, growing to high cell densities, and producing proteins in a cost-effective...
4.
-Palmitoylation during Retinoic Acid-Induced Neuronal Differentiation of SH-SY5Y Neuroblastoma Cells
Sardana S, Nederstigt A, Baggelaar M
J Proteome Res
. 2023 Jun;
22(7):2421-2435.
PMID: 37294931
-Palmitoylation is the covalent attachment of C14:0-C22:0 fatty acids (mainly C16:0 palmitate) to cysteines via thioester bonds. This lipid modification is highly abundant in neurons, where it plays a role...
5.
Welsh K, Bolhuis D, Nederstigt A, Boyer J, Temple B, Bonacci T, et al.
EMBO J
. 2021 Dec;
41(3):e108823.
PMID: 34942047
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)-conjugating (UBC) domain that forms...