Joseph S Harrison
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Explore the profile of Joseph S Harrison including associated specialties, affiliations and a list of published articles.
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32
Citations
807
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Recent Articles
1.
Bukhari Z, Gu L, Nederstigt A, Cope L, Bolhuis D, Harvey K, et al.
bioRxiv
. 2024 Sep;
PMID: 39282319
Ubiquitin (Ub) is a post-translational modification that largely controls proteostasis through mechanisms spanning transcription, translation, and notably, protein degradation. Ub conjugation occurs through a hierarchical cascade of three enzyme classes...
2.
Bodrug T, Welsh K, Bolhuis D, Paulakonis E, Martinez-Chacin R, Liu B, et al.
Nat Struct Mol Biol
. 2023 Sep;
30(11):1663-1674.
PMID: 37735619
Substrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped...
3.
Irshad B, Lu C, Nederstigt A, Hu P, Xue L, Lin-Cereghino J, et al.
Protein Expr Purif
. 2023 Aug;
212:106355.
PMID: 37598731
Pichia pastoris, a methylotrophic yeast used for recombinant protein expression, has the capability of performing many eukaryotic post-translational modifications, growing to high cell densities, and producing proteins in a cost-effective...
4.
Wick E, Treadway C, Li Z, Nicely N, Ren Z, Baldwin A, et al.
J Virol
. 2022 Aug;
96(17):e0082622.
PMID: 35938868
Viruses evolve mechanisms to exploit cellular pathways that increase viral fitness, e.g., enhance viral replication or evade the host cell immune response. The ubiquitin-proteosome system, a fundamental pathway-regulating protein fate...
5.
King K, Larsen B, Gryseels S, Richet C, Kraberger S, Jackson R, et al.
mBio
. 2022 Mar;
13(2):e0005422.
PMID: 35311536
Upon infection, DNA viruses can be sensed by pattern recognition receptors (PRRs), leading to the activation of type I and III interferons to block infection. Therefore, viruses must inhibit these...
6.
Pulavarti S, Maguire J, Yuen S, Harrison J, Griffin J, Premkumar L, et al.
J Phys Chem B
. 2022 Feb;
126(6):1212-1231.
PMID: 35128921
Understanding protein folding is crucial for protein sciences. The conformational spaces and energy landscapes of cold (unfolded) protein states, as well as the associated transitions, are hardly explored. Furthermore, it...
7.
Welsh K, Bolhuis D, Nederstigt A, Boyer J, Temple B, Bonacci T, et al.
EMBO J
. 2021 Dec;
41(3):e108823.
PMID: 34942047
Polyubiquitination by E2 and E3 enzymes is crucial to cell cycle control, epigenetic regulation, and development. The hallmark of the E2 family is the ubiquitin (Ub)-conjugating (UBC) domain that forms...
8.
Weston K, Gao X, Zhao J, Kim K, Maloney S, Gotoff J, et al.
Nat Commun
. 2021 Nov;
12(1):6809.
PMID: 34815418
The mechanisms that underlie the extensive phenotypic diversity in genetic disorders are poorly understood. Here, we develop a large-scale assay to characterize the functional valence (gain or loss-of-function) of missense...
9.
Petell C, Randene K, Pappas M, Sandoval D, Strahl B, Harrison J, et al.
Elife
. 2021 Sep;
10.
PMID: 34581668
Measuring protein-protein interaction (PPI) affinities is fundamental to biochemistry. Yet, conventional methods rely upon the law of mass action and cannot measure many PPIs due to a scarcity of reagents...
10.
Franks J, Martinez-Chacin R, Wang X, Tiedemann R, Bonacci T, Choudhury R, et al.
PLoS Biol
. 2020 Dec;
18(12):e3000975.
PMID: 33306668
The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression. Despite its vital role, it has remained challenging to globally map APC/C substrates. By...