Anne-Marie L Hogan
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Explore the profile of Anne-Marie L Hogan including associated specialties, affiliations and a list of published articles.
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16
Citations
617
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Recent Articles
1.
Zhang B, Carroll J, Trojanowski J, Yao Y, Iba M, Potuzak J, et al.
J Neurosci
. 2012 Mar;
32(11):3601-11.
PMID: 22423084
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased phosphorylation and decreased solubility has been proposed to diminish normal...
2.
Smith 3rd A, Hogan A, Liu Z, Razler T, Meis R, Morinaka B, et al.
Tetrahedron
. 2011 Aug;
67(27-28):5069-5078.
PMID: 21811346
The design, synthesis and biological evaluation of a new phorboxazole analogue, comprising an acetal replacement for the C-ring tetrahdropyran of the natural product and carrying a potency-enhancing C(45-46) vinyl chloride...
3.
Ebetino F, Hogan A, Sun S, Tsoumpra M, Duan X, Triffitt J, et al.
Bone
. 2011 Apr;
49(1):20-33.
PMID: 21497677
The ability of bisphosphonates ((HO)(2)P(O)CR(1)R(2)P(O)(OH)(2)) to inhibit bone resorption has been known since the 1960s, but it is only recently that a detailed molecular understanding of the relationship between chemical...
4.
Brunden K, Yao Y, Potuzak J, Ferrer N, Ballatore C, James M, et al.
Pharmacol Res
. 2010 Dec;
63(4):341-51.
PMID: 21163349
Tau, a protein that is enriched in neurons of the central nervous system (CNS), is thought to play a critical role in the stabilization of microtubules (MTs). Several neurodegenerative disorders...
5.
Brunden K, Zhang B, Carroll J, Yao Y, Potuzak J, Hogan A, et al.
J Neurosci
. 2010 Oct;
30(41):13861-6.
PMID: 20943926
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary tangles comprised of hyperphosphorylated tau protein. Tau normally stabilizes microtubules (MTs), and tau...
6.
Smith 3rd A, Liu Z, Hogan A, Dalisay D, Molinski T
Org Lett
. 2009 Jul;
11(16):3766-9.
PMID: 19637861
A synthesis providing totally synthetic (+)-hemi-phorboxazole A (1), proceeding in two steps (85% yield) from known vinyl iodide precursor (+)-2, has been achieved in conjunction with the design, synthesis, and...
7.
Crowe A, Huang W, Ballatore C, Johnson R, Hogan A, Huang R, et al.
Biochemistry
. 2009 Jul;
48(32):7732-45.
PMID: 19580328
Inclusions comprised of fibrils of the microtubule- (MT-) associated protein tau are found in the brains of those with Alzheimer's disease (AD) and other neurodegenerative tauopathies. The pathology that is...
8.
Tricotet T, Fleming P, Cotter J, Hogan A, Strohmann C, Gessner V, et al.
J Am Chem Soc
. 2009 Feb;
131(9):3142-3.
PMID: 19226124
A stereochemistry-controlled suppression of carbolithiation facilitated a regioselective vinyl C-H lithiation of cis-stilbenes allowing routine regio- and stereoselective access to polysubstituted alkenes and heterocycles. This unique selectivity was obtained for...
9.
Hogan A, OShea D
Chem Commun (Camb)
. 2008 Aug;
(33):3839-51.
PMID: 18726011
Carbolithiation reactions are exceptionally versatile transformations which have been utilised in a remarkably diverse and creative manner. In this review we outline the background and scope of these reactions and...
10.
Hogan A, Tricotet T, Meek A, Khokhar S, OShea D
J Org Chem
. 2008 Jul;
73(15):6041-4.
PMID: 18588347
The enantioselective carbolithiation of ortho-substituted (E)-beta-methylstyrenes provides access to chiral lithiated intermediates with broad synthetic potential. Specifically, beta-methylstyrenes with o-aminomethyl, ether, and oxazoline groups have been employed in the synthesis...