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Anne-Marie Fortier

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Articles 16
Citations 355
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Recent Articles
1.
Gu Y, Taifour T, Bui T, Zuo D, Pacis A, Poirier A, et al.
Nat Commun . 2024 Oct; 15(1):9174. PMID: 39448577
Recurrent breast cancers often develop resistance to standard-of-care therapies. Identifying targetable factors contributing to cancer recurrence remains the rate-limiting step in improving long-term outcomes. In this study, we identify tumor...
2.
Khalil A, Smits D, Haughton P, Koorman T, Jansen K, Verhagen M, et al.
Nat Commun . 2024 Jun; 15(1):4866. PMID: 38849373
Dense and aligned Collagen I fibers are associated with collective cancer invasion led by protrusive tumor cells, leader cells. In some breast tumors, a population of cancer cells (basal-like cells)...
3.
Gagnon A, Fortier A, Audette C
Insects . 2024 Apr; 15(4). PMID: 38667362
Onion thrips () can pose a significant threat to onion crops, causing leaf damage, reduced bulb size and quality, and yield loss during severe infestations. Conventional insecticide use has been...
4.
Kuzmin E, Baker T, Lesluyes T, Monlong J, Abe K, Coelho P, et al.
Cell Rep . 2024 Mar; 43(4):113988. PMID: 38517886
The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in...
5.
Nandi I, Smith H, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, et al.
J Clin Invest . 2023 Feb; 133(7). PMID: 36795481
Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we have shown that deletion of c-Src in a...
6.
Brewer G, Fortier A, Park M, Moraes C
Future Drug Discov . 2022 May; 4(1):FDD71. PMID: 35600290
Although cancer-associated fibroblasts (CAFs) have gained increased attention for supporting cancer progression, current CAF-targeted therapeutic options are limited and failing in clinical trials. As the largest component of the tumor...
7.
Biondini M, Kiepas A, El-Houjeiri L, Annis M, Hsu B, Fortier A, et al.
Oncogene . 2022 Feb; 41(12):1701-1717. PMID: 35110681
Transmembrane glycoprotein NMB (GPNMB) is a prognostic marker of poor outcome in patients with triple-negative breast cancer (TNBC). Glembatumumab Vedotin, an antibody drug conjugate targeting GPNMB, exhibits variable efficacy against...
8.
Ghanbari F, Fortier A, Park M, Philip A
Cancers (Basel) . 2021 Jun; 13(11). PMID: 34073320
The molecular mechanism underlying the metabolic reprogramming associated with obesity and high blood cholesterol levels is poorly understood. We previously reported that cholesterol is an endogenous ligand of the estrogen-related...
9.
Van der Heyden H, Fortier A, Savage J
J Econ Entomol . 2020 Oct; 113(6):2920-2930. PMID: 33080027
The seedcorn maggot Delia platura (Meigen), and the bean seed maggot Delia florilega (Zetterstedt) can cause considerable feeding damage to a wide range of cultivated crops. The recent discovery of...
10.
Wu Q, Ba-Alawi W, Deblois G, Cruickshank J, Duan S, Lima-Fernandes E, et al.
Nat Commun . 2020 Aug; 11(1):4205. PMID: 32826891
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers...