Anna V Molofsky
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Explore the profile of Anna V Molofsky including associated specialties, affiliations and a list of published articles.
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4809
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Recent Articles
1.
Nakajo H, Cao R, Mula S, McKetney J, Silva N, Shah M, et al.
bioRxiv
. 2025 Mar;
PMID: 40060405
Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates synaptic plasticity via mechanisms that are still being defined and are studied predominantly in...
2.
Mroz N, Ciesielska A, Ewing-Crystal N, Dorman L, Han R, Barron J, et al.
bioRxiv
. 2025 Jan;
PMID: 39763918
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide and can lead to secondary sequelae such as increased seizure susceptibility. Emerging work suggests that the thalamus,...
3.
Silva N, Anderson S, Mula S, Escoubas C, Nakajo H, Molofsky A
bioRxiv
. 2024 Dec;
PMID: 39677624
Half of all newborn neurons in the developing brain are removed via efferocytosis - the phagocytic clearance of apoptotic cells. Microglia are brain-resident professional phagocytes that play important roles in...
4.
Barron J, Mroz N, Taloma S, Dahlgren M, Ortiz-Carpena J, Keefe M, et al.
Science
. 2024 Oct;
386(6721):eadi1025.
PMID: 39480923
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits....
5.
Escoubas C, Molofsky A
Trends Immunol
. 2024 Apr;
45(5):358-370.
PMID: 38658221
Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms through which mammalian microglia...
6.
Escoubas C, Dorman L, Nguyen P, Lagares-Linares C, Nakajo H, Anderson S, et al.
Cell
. 2024 Mar;
187(8):1936-1954.e24.
PMID: 38490196
Microglia are brain-resident macrophages that shape neural circuit development and are implicated in neurodevelopmental diseases. Multiple microglial transcriptional states have been defined, but their functional significance is unclear. Here, we...
7.
Rosenberg M, Godoy M, Wade S, Paredes M, Zhang Y, Molofsky A
J Neurosci
. 2023 Oct;
43(50):8621-8636.
PMID: 37845031
Astrocytes play essential roles in the developing nervous system, including supporting synapse function. These astrocyte support functions emerge coincident with brain maturation and may be tailored in a region-specific manner....
8.
Barron J, Mroz N, Taloma S, Dahlgren M, Ortiz-Carpena J, Dorman L, et al.
bioRxiv
. 2023 Mar;
PMID: 36993292
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2...
9.
Han R, Vainchtein I, Schlachetzki J, Cho F, Dorman L, Ahn E, et al.
J Exp Med
. 2022 Dec;
220(2).
PMID: 36520518
Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here,...
10.
Cho F, Vainchtein I, Voskobiynyk Y, Morningstar A, Aparicio F, Higashikubo B, et al.
Sci Transl Med
. 2022 Jul;
14(652):eabj4310.
PMID: 35857628
Inflammatory processes induced by brain injury are important for recovery; however, when uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory treatments have failed to improve neurological outcomes after...