Anna-Liisa Nieminen
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Explore the profile of Anna-Liisa Nieminen including associated specialties, affiliations and a list of published articles.
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24
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804
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Recent Articles
1.
Hu J, Nieminen A, Zhong Z, Lemasters J
Livers
. 2024 Nov;
4(3):333-351.
PMID: 39554796
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability transition (MPT). Reactive...
2.
Hu J, Nieminen A, Weemhoff J, Jaeschke H, Murphy L, Dent J, et al.
Toxicol Appl Pharmacol
. 2023 Oct;
479:116722.
PMID: 37848124
Acetaminophen (APAP) overdose disrupts hepatocellular lysosomes, which release ferrous iron (Fe) that translocates into mitochondria putatively via the mitochondrial calcium uniporter (MCU) to induce oxidative/nitrative stress, the mitochondrial permeability transition...
3.
Kholmukhamedov A, Li L, Lindsey C, Hu J, Nieminen A, Takemoto K, et al.
J Biol Chem
. 2022 Aug;
298(9):102336.
PMID: 35931111
Mitochondrial chelatable iron contributes to the severity of several injury processes, including ischemia/reperfusion, oxidative stress, and drug toxicity. However, methods to measure this species in living cells are lacking. To...
4.
Jetty R, Bandera Y, Daniele M, Hanor D, Hung H, Ramshesh V, et al.
J Mater Chem B
. 2020 Apr;
1(36):4542-4554.
PMID: 32261197
Sub-100 nm colloidal particles which are surface-functionalized with multiple environmentally-sensitive moieties have the potential to combine imaging, early detection, and the treatment of cancer with a single type of long-circulating...
5.
Domondon M, Polina I, Nikiforova A, Sultanova R, Kruger C, Vasileva V, et al.
Front Physiol
. 2020 Mar;
10:1588.
PMID: 32116733
Salt-sensitive (SS) hypertension is accompanied with an early onset of proteinuria, which results from the loss of glomerular podocytes. Here, we hypothesized that glomerular damage in the SS hypertension occurs...
6.
Burdette M, Jenkins R, Bandera Y, Jones H, Foulger I, Dickey A, et al.
ACS Appl Bio Mater
. 2019 Dec;
2(8):3183-3193.
PMID: 31844845
We present a multifunctional polymer based nanoparticle platform for personalized nanotheranostic applications, which include photodynamic therapy and active targeting. In this system, poly(propargyl acrylate) (PA) particles were surface-modified with organic...
7.
He H, Nieminen A, Xu P
Biomater Sci
. 2019 Oct;
7(12):5143-5149.
PMID: 31577285
Photodynamic therapy has attracted significant attention due to its localized treatment advantage. However, the non-specific distribution of photosensitizers and the subsequent potential toxicity caused by sunshine exposure hinder its wide...
8.
Qanungo S, Uys J, Manevich Y, Distler A, Shaner B, Hill E, et al.
Biomed Pharmacother
. 2014 Sep;
68(7):855-64.
PMID: 25257100
First-line therapy for pancreatic cancer is gemcitabine. Although tumors may initially respond to the gemcitabine treatment, soon tumor resistance develops leading to treatment failure. Previously, we demonstrated in human MIA...
9.
He H, Cattran A, Nguyen T, Nieminen A, Xu P
Biomaterials
. 2014 Aug;
35(35):9546-53.
PMID: 25154666
A pH, thermal, and redox potential triple-responsive expansile nanogel system (TRN), which swells at acidic pH, temperature higher than its transition temperature, and reducing environment, has been developed. TRN quickly...
10.
Hung H, Schwartz J, Maldonado E, Lemasters J, Nieminen A
J Biol Chem
. 2012 Nov;
288(1):677-86.
PMID: 23135267
Photodynamic therapy (PDT) is a promising approach to treat head and neck cancer cells. Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-induced cell killing. Three human...