Ann Friedman
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Explore the profile of Ann Friedman including associated specialties, affiliations and a list of published articles.
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20
Citations
484
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Recent Articles
1.
Everett L, Lin Z, Friedman A, Tang V, Myers G, Balbin-Cuesta G, et al.
JCI Insight
. 2024 Nov;
9(24).
PMID: 39499573
Thrombopoietin (TPO) is a plasma glycoprotein that binds its receptor on megakaryocytes (MKs) and MK progenitors, resulting in enhanced platelet production. The mechanism by which TPO is secreted from hepatocytes...
2.
Myers G, Wang Y, Wang Q, Friedman A, Sanchez-Martinez A, Liu X, et al.
Blood Adv
. 2023 Aug;
7(19):5727-5732.
PMID: 37552129
Our current understanding of the kinetics and dynamics of erythroid differentiation is based almost entirely on the ex vivo expansion of cultured hematopoietic progenitor cells. In this study, we used...
3.
King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, et al.
Sci Adv
. 2021 Nov;
7(48):eabj5293.
PMID: 34818036
Congenital dyserythropoietic anemia type II (CDAII) results from loss-of-function mutations in . In contrast to humans, SEC23B-deficient mice deletion do not exhibit CDAII but die perinatally with pancreatic degeneration. Here,...
4.
Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
Graniel J, Bisht K, Friedman A, White J, Perkey E, Vanderbeck A, et al.
Life Sci Alliance
. 2021 Oct;
5(1).
PMID: 34645668
Telomerase extends chromosome ends in somatic and germline stem cells to ensure continued proliferation. Mutations in genes critical for telomerase function result in telomeropathies such as dyskeratosis congenita, frequently resulting...
5.
Grill S, Padmanaban S, Friedman A, Perkey E, Allen F, Tesmer V, et al.
JCI Insight
. 2021 Apr;
6(9).
PMID: 33822766
Telomerase catalyzes chromosome end replication in stem cells and other long-lived cells. Mutations in telomerase or telomere-related genes result in diseases known as telomeropathies. Telomerase is recruited to chromosome ends...
6.
Grigsby S, Friedman A, Chase J, Waas B, Ropa J, Serio J, et al.
Cancers (Basel)
. 2021 Feb;
13(4).
PMID: 33562706
gene rearrangements underlie the pathogenesis of aggressive MLL-driven acute leukemia. AF9, one of the most common MLL-fusion partners, recruits the histone H3K79 methyltransferase DOT1L to MLL target genes, constitutively activating...
7.
Lin Z, King R, Tang V, Myers G, Balbin-Cuesta G, Friedman A, et al.
Mol Cell Biol
. 2020 Sep;
40(23).
PMID: 32989016
Erythropoietin (EPO) stimulates erythroid differentiation and maturation. Though the transcriptional regulation of EPO has been well studied, the molecular determinants of EPO secretion remain unknown. Here, we generated a HEK293T...
8.
Chung J, Radojcic V, Perkey E, Parnell T, Niknafs Y, Jin X, et al.
J Immunol
. 2019 Jun;
203(2):557-568.
PMID: 31182480
Graft-versus-host disease (GVHD) is the most serious complication of allogeneic hematopoietic cell transplantation. Notch signals delivered during the first 48 h after transplantation drive proinflammatory cytokine production in conventional T...
9.
Saha N, Ropa J, Chen L, Hu H, Mysliwski M, Friedman A, et al.
Stem Cell Reports
. 2019 Apr;
12(5):1069-1083.
PMID: 31031188
The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fusion-driven acute myeloid leukemia (AML) through direct regulation...
10.
Radojcic V, Paz K, Chung J, Du J, Perkey E, Flynn R, et al.
Blood
. 2018 Sep;
132(20):2188-2200.
PMID: 30181175
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT) and remains an area of unmet clinical need with few treatment options available. Notch blockade prevents...