Ankur A Gholkar
Overview
Explore the profile of Ankur A Gholkar including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
197
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0
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Recent Articles
1.
Abdusamad M, Guo X, Ramirez I, Velasquez E, Cohn W, Gholkar A, et al.
bioRxiv
. 2025 Jan;
PMID: 39868293
Protein phosphatases are critical for regulating cell signaling, cell cycle, and cell fate decisions, and their dysregulation leads to an array of human diseases like cancer. The dual specificity phosphatases...
2.
Clutario K, Abdusamad M, Ramirez I, Rich K, Gholkar A, Zaragoza J, et al.
bioRxiv
. 2025 Jan;
PMID: 39829749
Human REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken multidisciplinary...
3.
Gholkar A, Gimeno T, Edgemon J, Sim M, Torres J
ACS Chem Biol
. 2024 Aug;
19(8):1733-1742.
PMID: 39106364
Primary cilia are membrane-covered microtubule-based structures that protrude from the cell surface and are critical for cell signaling and homeostasis during human development and adulthood. Dysregulation of cilia formation, length,...
4.
Velasquez E, Garcia Y, Ramirez I, Gholkar A, Torres J
Mol Biol Cell
. 2021 Aug;
32(21):br9.
PMID: 34432510
The elucidation of a protein's interaction/association network is important for defining its biological function. Mass spectrometry-based proteomic approaches have emerged as powerful tools for identifying protein-protein interactions (PPIs) and protein-protein...
5.
Garcia Y, Velasquez E, Gao L, Gholkar A, Clutario K, Cheung K, et al.
J Proteome Res
. 2021 Jun;
20(7):3414-3427.
PMID: 34087075
The spindle assembly checkpoint (SAC) is critical for sensing defective microtubule-kinetochore attachments and tension across the kinetochore and functions to arrest cells in prometaphase to allow time to repair any...
6.
Guo X, Ramirez I, Garcia Y, Velasquez E, Gholkar A, Cohn W, et al.
J Biol Chem
. 2021 Apr;
296:100676.
PMID: 33865857
Human cell division is a highly regulated process that relies on the accurate capture and movement of chromosomes to the metaphase plate. Errors in the fidelity of chromosome congression and...
7.
Ramirez I, Gholkar A, Velasquez E, Guo X, Tofig B, Damoiseaux R, et al.
Cytoskeleton (Hoboken)
. 2021 Feb;
78(2):23-35.
PMID: 33641240
Myosins are ATP-dependent actin-based molecular motors critical for diverse cellular processes like intracellular trafficking, cell motility, and cell invasion. During cell division, myosin MYO10 is important for proper mitotic spindle...
8.
Gholkar A, Schmollinger S, Velasquez E, Lo Y, Cohn W, Capri J, et al.
Biochemistry
. 2020 Aug;
59(32):2916-2921.
PMID: 32786404
Somatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinson's disease. Lactotransferrin (LTF) is a member of the family of...
9.
Sawicki M, Gholkar A, Torres J
Endocrinology
. 2019 Jun;
160(8):1926-1936.
PMID: 31211356
Menin is the protein mutated in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome and their corresponding sporadic tumor counterparts. We have found that menin functions in promoting proper...
10.
Xia X, Lo Y, Gholkar A, Senese S, Ong J, Velasquez E, et al.
ACS Chem Biol
. 2019 May;
14(5):994-1001.
PMID: 31046221
Targeting the leukemia proliferation cycle has been a successful approach to developing antileukemic therapies. However, drug screening efforts to identify novel antileukemic agents have been hampered by the lack of...