Anke Penno
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Explore the profile of Anke Penno including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
791
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Recent Articles
1.
Lauterbach M, Saavedra V, Mangan M, Penno A, Thiele C, Latz E, et al.
Autophagy
. 2020 Aug;
17(8):1947-1961.
PMID: 32835606
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity...
2.
Dogbevia G, Grasshoff H, Othman A, Penno A, Schwaninger M
J Cereb Blood Flow Metab
. 2019 Jul;
40(6):1338-1350.
PMID: 31357902
In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme β-hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers neurodegeneration. Although the pathology centers on neurons,...
3.
Schonauer S, Korschen H, Penno A, Rennhack A, Breiden B, Sandhoff K, et al.
J Biol Chem
. 2017 Mar;
292(15):6177-6189.
PMID: 28258214
The lysosomal acid β-glucosidase GBA1 and the non-lysosomal β-glucosidase GBA2 degrade glucosylceramide (GlcCer) to glucose and ceramide in different cellular compartments. Loss of GBA2 activity and the resulting accumulation of...
4.
Alecu I, Tedeschi A, Behler N, Wunderling K, Lamberz C, Lauterbach M, et al.
J Lipid Res
. 2016 Nov;
58(1):42-59.
PMID: 27881717
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and...
5.
Alecu I, Othman A, Penno A, Saied E, Arenz C, von Eckardstein A, et al.
J Lipid Res
. 2016 Nov;
58(1):60-71.
PMID: 27872144
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and...
6.
Gaebler A, Penno A, Kuerschner L, Thiele C
J Lipid Res
. 2016 Aug;
57(10):1934-1947.
PMID: 27565170
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be...
7.
Ernst D, Murphy S, Sathiyanadan K, Wei Y, Othman A, Laura M, et al.
Neuromolecular Med
. 2015 Jan;
17(1):47-57.
PMID: 25567748
1-Deoxysphingolipids (1-deoxySL) are atypical sphingolipids that are formed by the enzyme serine palmitoyltransferase (SPT) due to a promiscuous use of L-alanine over its canonical substrate L-serine. Several mutations in SPT...
8.
Penno A, Hackenbroich G, Thiele C
Biochim Biophys Acta
. 2012 Dec;
1831(3):589-94.
PMID: 23246574
Lipid droplets are ubiquitous cellular organelles that allow cells to store large amounts of neutral lipids for membrane synthesis and energy supply in times of starvation. Compared to other cellular...
9.
Garofalo K, Penno A, Schmidt B, Lee H, Frosch M, von Eckardstein A, et al.
J Clin Invest
. 2011 Nov;
121(12):4735-45.
PMID: 22045570
Hereditary sensory and autonomic neuropathy type 1 (HSAN1) causes sensory loss that predominantly affects the lower limbs, often preceded by hyperpathia and spontaneous shooting or lancinating pain. It is caused...
10.
Rotthier A, Penno A, Rautenstrauss B, Auer-Grumbach M, Stettner G, Asselbergh B, et al.
Hum Mutat
. 2011 May;
32(6):E2211-25.
PMID: 21618344
Hereditary sensory and autonomic neuropathy type I (HSAN-I) is an axonal peripheral neuropathy leading to progressive distal sensory loss and severe ulcerations. Mutations in SPTLC1 and SPTLC2, encoding the two...