Anita L Steptoe
Overview
Explore the profile of Anita L Steptoe including associated specialties, affiliations and a list of published articles.
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8
Citations
1591
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Recent Articles
1.
Martin H, Wani S, Steptoe A, Krishnan K, Nones K, Nourbakhsh E, et al.
Genome Biol
. 2014 Mar;
15(3):R51.
PMID: 24629056
Background: MicroRNAs (miRNAs) bind to mRNAs and target them for translational inhibition or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the seed region at the 5' end...
2.
Krishnan K, Steptoe A, Martin H, Pattabiraman D, Nones K, Waddell N, et al.
RNA
. 2013 Oct;
19(12):1767-80.
PMID: 24158791
Metastasis is a complex, multistep process involved in the progression of cancer from a localized primary tissue to distant sites, often characteristic of the more aggressive forms of this disease....
3.
Krishnan K, Steptoe A, Martin H, Wani S, Nones K, Waddell N, et al.
RNA
. 2012 Dec;
19(2):230-42.
PMID: 23249749
MicroRNAs are noncoding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive tumorigenesis in cancer, but functional studies to understand...
4.
Cloonan N, Wani S, Xu Q, Gu J, Lea K, Heater S, et al.
Genome Biol
. 2012 Jan;
12(12):R126.
PMID: 22208850
Background: Variants of microRNAs (miRNAs), called isomiRs, are commonly reported in deep-sequencing studies; however, the functional significance of these variants remains controversial. Observational studies show that isomiR patterns are non-random,...
5.
Faulkner G, Kimura Y, Daub C, Wani S, Plessy C, Irvine K, et al.
Nat Genet
. 2009 Apr;
41(5):563-71.
PMID: 19377475
Although repetitive elements pervade mammalian genomes, their overall contribution to transcriptional activity is poorly defined. Here, as part of the FANTOM4 project, we report that 6-30% of cap-selected mouse and...
6.
Cloonan N, Brown M, Steptoe A, Wani S, Chan W, Forrest A, et al.
Genome Biol
. 2008 Aug;
9(8):R127.
PMID: 18700987
Background: MicroRNAs are modifiers of gene expression, acting to reduce translation through either translational repression or mRNA cleavage. Recently, it has been shown that some microRNAs can act to promote...
7.
Cloonan N, Forrest A, Kolle G, Gardiner B, Faulkner G, Brown M, et al.
Nat Methods
. 2008 Jun;
5(7):613-9.
PMID: 18516046
We developed a massive-scale RNA sequencing protocol, short quantitative random RNA libraries or SQRL, to survey the complexity, dynamics and sequence content of transcriptomes in a near-complete fashion. This method...
8.
Bruce S, Rea R, Steptoe A, Busslinger M, Bertram J, Perkins A
Differentiation
. 2007 Feb;
75(5):337-49.
PMID: 17286599
Embryonic stem (ES) cells have the capacity to differentiate into all cells of the developing embryo and may provide a renewable resource for future cell replacement therapies. The addition of...