Alistair R R Forrest
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Explore the profile of Alistair R R Forrest including associated specialties, affiliations and a list of published articles.
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132
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11787
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Recent Articles
1.
Chin W, Cook A, Chee J, Principe N, Hoang T, Kidman J, et al.
Cell Rep Med
. 2024 Dec;
6(1):101882.
PMID: 39731918
Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers...
2.
Amit I, Ardlie K, Arzuaga F, Awandare G, Bader G, Bernier A, et al.
Nat Commun
. 2024 Nov;
15(1):10019.
PMID: 39567491
The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human...
3.
Dalla E, Papanicolaou M, Park M, Barth N, Hou R, Segura-Villalobos D, et al.
Cell
. 2024 Oct;
187(23):6631-6648.e20.
PMID: 39378878
Breast disseminated cancer cells (DCCs) can remain dormant in the lungs for extended periods, but the mechanisms limiting their expansion are not well understood. Research indicates that tissue-resident alveolar macrophages...
4.
Chin W, Zemek R, Tilsed C, Forrest A, Fear V, Forbes C, et al.
Sci Data
. 2024 May;
11(1):448.
PMID: 38702329
Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present...
5.
Kidman J, Zemek R, Sidhom J, Correa D, Principe N, Sheikh F, et al.
Oncoimmunology
. 2024 Apr;
13(1):2345859.
PMID: 38686178
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the...
6.
Denisenko E, de Kock L, Tan A, Beasley A, Beilin M, Jones M, et al.
Nat Commun
. 2024 Apr;
15(1):2860.
PMID: 38570491
High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Here,...
7.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan C, et al.
Sci Adv
. 2023 Sep;
9(37):eadh0831.
PMID: 37703359
The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor. There are no approved treatments to...
8.
Carlessi R, Denisenko E, Boslem E, Kohn-Gaone J, Main N, Abu Bakar N, et al.
Cell Genom
. 2023 May;
3(5):100301.
PMID: 37228755
Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and...
9.
Cabanes-Creus M, Navarro R, Liao S, Scott S, Carlessi R, Roca-Pinilla R, et al.
Mol Ther Methods Clin Dev
. 2023 Jan;
28:220-237.
PMID: 36700121
Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical target, given its critical physiological functions and involvement...
10.
Herring C, Simmons R, Freytag S, Poppe D, Moffet J, Pflueger J, et al.
Cell
. 2022 Nov;
185(23):4428-4447.e28.
PMID: 36318921
Human brain development is underpinned by cellular and molecular reconfigurations continuing into the third decade of life. To reveal cell dynamics orchestrating neural maturation, we profiled human prefrontal cortex gene...