Anisha Kothari
Overview
Explore the profile of Anisha Kothari including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
239
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0
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Recent Articles
1.
Delgado M, Kothari A, Hittelman W, Chambers T
J Vis Exp
. 2017 Nov;
(129).
PMID: 29155772
The ability to synchronize cells has been central to advancing our understanding of cell cycle regulation. Common techniques employed include serum deprivation; chemicals which arrest cells at different cell cycle...
2.
Opferman J, Kothari A
Cell Death Differ
. 2017 Nov;
25(1):37-45.
PMID: 29099482
Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2) prevents the induction of apoptosis not only in malignant cells, but also in normal cellular lineages. This...
3.
Budhraja A, Turnis M, Churchman M, Kothari A, Yang X, Xu H, et al.
Clin Cancer Res
. 2017 Oct;
23(24):7558-7568.
PMID: 28974549
BCR-ABL B-ALL leukemic cells are highly dependent on the expression of endogenous antiapoptotic MCL-1 to promote viability and are resistant to BH3-mimetic agents such as navitoclax (ABT-263) that target BCL-2,...
4.
Chu R, Alford S, Hart K, Kothari A, Mackintosh S, Kovak M, et al.
Oncotarget
. 2016 Oct;
7(48):78958-78970.
PMID: 27738316
Microtubule targeting agents (MTAs) characteristically promote phosphorylation and degradation of Mcl-1, and this represents a critical pro-apoptotic signal in mitotic death. While several phosphorylation sites and kinases have been implicated...
5.
Kothari A, Hittelman W, Chambers T
Cancer Res
. 2016 May;
76(12):3553-61.
PMID: 27197148
Microtubule-targeting agents (MTA), such as the taxanes and vinca alkaloids, are used to treat a variety of cancers due to their ability to perturb microtubule dynamics. In cell culture, MTAs...
6.
7.
Alford S, Kothari A, Loeff F, Eichhorn J, Sakurikar N, Goselink H, et al.
Cancer Res
. 2015 Feb;
75(7):1366-75.
PMID: 25649768
BH3 mimetic drugs may be useful to treat acute lymphoblastic leukemia (ALL) but the sensitivity of primary tumor cells has not been fully evaluated. Here, B-lineage ALL cell cultures derived...
8.
Eichhorn J, Kothari A, Chambers T
PLoS One
. 2014 Nov;
9(11):e113283.
PMID: 25415322
Microtubule inhibitors are widely used in cancer chemotherapy. These drugs characteristically induce mitotic arrest and cell death but the mechanisms linking the two are not firmly established. One of the...